Chromosomal imbalances in familial chronic lymphocytic leukemia: A comparative genomic hybridisation analysis

B. Summersgill; P. Thornton; S. Atkinson; J. Shipley; D. Catovsky; R. S. Houlston; M. R. Yuille

doi:10.1038/sj.leu.2402321

Chromosomal imbalances in familial chronic lymphocytic leukemia: A comparative genomic hybridisation analysis

B. Summersgill, P. Thornton, S. Atkinson, J. Shipley, D. Catovsky, R. S. Houlston, M. R. Yuille

Research output: Contribution to journal › Article › peer-review

Abstract

A subset of B cell chronic lymphocytic leukaemia (CLL) is familial. Lack of large families makes it attractive to exploit methods in addition to genetic linkage analysis for the identification of a susceptibility locus. One strategy that can localise regions of the genome that may harbour tumour suppressor genes is to identify regions of chromosomal imbalance using comparative genomic hybridisation (CGH) analysis. We examined 24 familial CLL cases by CGH analysis. Losses that are documented as arising frequently in sporadic CLL were observed at a comparable frequency in familial CLL. However, gains and losses in two regions of the X chromosome-Xp11.2-p21 and Xq21-qter - appear more common in familial CLL than in sporadic CLL. This suggests these regions may harbour a susceptibility locus for CLL. There is also some evidence that chromosome regions 2p 12-p14 and 4q11-q21 may harbour predisposition genes.

Original language	English
Pages (from-to)	1229-1232
Number of pages	3
Journal	Leukemia
Volume	16
Issue number	7
DOIs	https://doi.org/10.1038/sj.leu.2402321
Publication status	Published - 2002

Keywords

Comparative genomic hybridisation
Familial chronic lymphocytic leukaemia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.leu.2402321

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title = "Chromosomal imbalances in familial chronic lymphocytic leukemia: A comparative genomic hybridisation analysis",

abstract = "A subset of B cell chronic lymphocytic leukaemia (CLL) is familial. Lack of large families makes it attractive to exploit methods in addition to genetic linkage analysis for the identification of a susceptibility locus. One strategy that can localise regions of the genome that may harbour tumour suppressor genes is to identify regions of chromosomal imbalance using comparative genomic hybridisation (CGH) analysis. We examined 24 familial CLL cases by CGH analysis. Losses that are documented as arising frequently in sporadic CLL were observed at a comparable frequency in familial CLL. However, gains and losses in two regions of the X chromosome-Xp11.2-p21 and Xq21-qter - appear more common in familial CLL than in sporadic CLL. This suggests these regions may harbour a susceptibility locus for CLL. There is also some evidence that chromosome regions 2p 12-p14 and 4q11-q21 may harbour predisposition genes.",

keywords = "Comparative genomic hybridisation, Familial chronic lymphocytic leukaemia",

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doi = "10.1038/sj.leu.2402321",

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T1 - Chromosomal imbalances in familial chronic lymphocytic leukemia: A comparative genomic hybridisation analysis

AU - Summersgill, B.

AU - Thornton, P.

AU - Atkinson, S.

AU - Shipley, J.

AU - Catovsky, D.

AU - Houlston, R. S.

AU - Yuille, M. R.

N1 - DA - 20020702IS - 0887-6924 (Print)LA - engPT - Comparative StudyPT - Journal ArticlePT - Research Support, Non-U.S. Gov'tSB - IM

PY - 2002

Y1 - 2002

N2 - A subset of B cell chronic lymphocytic leukaemia (CLL) is familial. Lack of large families makes it attractive to exploit methods in addition to genetic linkage analysis for the identification of a susceptibility locus. One strategy that can localise regions of the genome that may harbour tumour suppressor genes is to identify regions of chromosomal imbalance using comparative genomic hybridisation (CGH) analysis. We examined 24 familial CLL cases by CGH analysis. Losses that are documented as arising frequently in sporadic CLL were observed at a comparable frequency in familial CLL. However, gains and losses in two regions of the X chromosome-Xp11.2-p21 and Xq21-qter - appear more common in familial CLL than in sporadic CLL. This suggests these regions may harbour a susceptibility locus for CLL. There is also some evidence that chromosome regions 2p 12-p14 and 4q11-q21 may harbour predisposition genes.

AB - A subset of B cell chronic lymphocytic leukaemia (CLL) is familial. Lack of large families makes it attractive to exploit methods in addition to genetic linkage analysis for the identification of a susceptibility locus. One strategy that can localise regions of the genome that may harbour tumour suppressor genes is to identify regions of chromosomal imbalance using comparative genomic hybridisation (CGH) analysis. We examined 24 familial CLL cases by CGH analysis. Losses that are documented as arising frequently in sporadic CLL were observed at a comparable frequency in familial CLL. However, gains and losses in two regions of the X chromosome-Xp11.2-p21 and Xq21-qter - appear more common in familial CLL than in sporadic CLL. This suggests these regions may harbour a susceptibility locus for CLL. There is also some evidence that chromosome regions 2p 12-p14 and 4q11-q21 may harbour predisposition genes.

KW - Comparative genomic hybridisation

KW - Familial chronic lymphocytic leukaemia

U2 - 10.1038/sj.leu.2402321

DO - 10.1038/sj.leu.2402321

M3 - Article

SN - 0887-6924

VL - 16

SP - 1229

EP - 1232

JO - Leukemia

JF - Leukemia

IS - 7

ER -

Chromosomal imbalances in familial chronic lymphocytic leukemia: A comparative genomic hybridisation analysis

Abstract

Keywords

UN SDGs

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