Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion

A L Corbi, R S Larson, T K Kishimoto, T A Springer, C C Morton

Research output: Contribution to journalArticlepeer-review

Abstract

The adhesion receptors Mac-1, LFA-1, and p150,95 are cell surface alpha/beta heterodimers that play a key role in leukocyte adhesion processes. The genes for Mac-1, LFA-1, and p150,95 alpha subunits have been located to chromosome 16 by means of Southern blot analysis using a series of somatic cell hybrids. Chromosomal in situ hybridization has demonstrated that the genes for the three alpha subunits map to the short arm of chromosome 16, between bands p11 and p13.1, defining a cluster of genes involved in leukocyte adhesion. The gene encoding the LFA-1/Mac-1/p150,95 beta subunit, and defective in leukocyte adhesion deficiency, has been located on chromosome 21, band q22. The leukocyte adhesion receptor alpha and beta subunits are mapped to chromosomal regions that have been shown to be involved in cytogenetic rearrangements in certain patients with acute myelomonocytic leukemia and the blast phase of chronic myelogenous leukemia, respectively.

Original languageEnglish
Pages (from-to)1597-607
Number of pages11
JournalThe Journal of experimental medicine
Volume167
Issue number5
Publication statusPublished - 1 May 1988

Keywords

  • Animals
  • Antigens, Surface
  • Cell Adhesion
  • Chromosome Mapping
  • Chromosomes, Human, Pair 16
  • Genes
  • Humans
  • Hybrid Cells
  • Lymphocyte Function-Associated Antigen-1
  • Macrophage-1 Antigen
  • Mice
  • Journal Article

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