Chronic fibrosing pulmonary aspergillosis: a cause of 'destroyed lung' syndrome

Chris Kosmidis, Pippa Newton, Eavan G Muldoon, David W Denning

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Chronic pulmonary aspergillosis (CPA) has substantial impact on quality of life. A subset of patients develops significant pulmonary fibrosis, identified either on biopsy or radiologically. The term chronic fibrosing pulmonary aspergillosis (CFPA) has been suggested.

METHODS: We describe 11 patients with CFPA referred to our centre.

RESULTS: Mean age was 58.5 years and five were male. In nine, fibrosis was already evident on presentation, while in two it developed 3 and 6 years later. The predominant radiological feature was extensive or complete involvement of the entire lung, with minimal contralateral involvement. All patients received prolonged antifungal treatment. Two patients had surgical treatment; both developed post-operative complications. The contralateral lung remained free of significant disease in all but three patients.

CONCLUSIONS: CFPA is a rare complication of CPA that is usually evident on presentation, but may develop after years in patients not on antifungals. Fibrosis resembles the 'destroyed lung' syndrome described after treated tuberculosis.

Original languageEnglish
Pages (from-to)296-301
Number of pages6
JournalInfectious diseases
Issue number4
Early online date23 Sept 2016
Publication statusPublished - Apr 2017


  • Adult
  • Aged
  • Chronic Disease
  • Female
  • Fibrosis/diagnostic imaging
  • Humans
  • Lung/diagnostic imaging
  • Male
  • Middle Aged
  • Pulmonary Aspergillosis/complications
  • Radiography, Thoracic
  • Retrospective Studies
  • Tomography, X-Ray Computed


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