Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib

H G Hamzah; A Pierce; W A Stewart; C Peter Downes; A Gray; A Irvine; E Spooncer; A D Whetton

doi:10.1038/sj.leu.2403919

Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib

H G Hamzah, A Pierce, W A Stewart, C Peter Downes, A Gray, A Irvine, E Spooncer, A D Whetton

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1851-3
Number of pages	3
Journal	Leukemia
Volume	19
Issue number	10
DOIs	https://doi.org/10.1038/sj.leu.2403919
Publication status	Published - Oct 2005

Keywords

Antigens, CD34
Benzamides
Chemotactic Factors
Cytokines
Humans
Imatinib Mesylate
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Lymphocytes
Phosphatidylinositol Phosphates
Piperazines
Pyrimidines

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10.1038/sj.leu.2403919

Cite this

Hamzah, H. G., Pierce, A., Stewart, W. A., Peter Downes, C., Gray, A., Irvine, A., Spooncer, E., & Whetton, A. D. (2005). Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib. Leukemia, 19(10), 1851-3. https://doi.org/10.1038/sj.leu.2403919

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title = "Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib",

keywords = "Antigens, CD34, Benzamides, Chemotactic Factors, Cytokines, Humans, Imatinib Mesylate, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Lymphocytes, Phosphatidylinositol Phosphates, Piperazines, Pyrimidines",

author = "Hamzah, {H G} and A Pierce and Stewart, {W A} and {Peter Downes}, C and A Gray and A Irvine and E Spooncer and Whetton, {A D}",

year = "2005",

month = oct,

doi = "10.1038/sj.leu.2403919",

language = "English",

volume = "19",

pages = "1851--3",

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Hamzah, HG, Pierce, A, Stewart, WA, Peter Downes, C, Gray, A, Irvine, A, Spooncer, E & Whetton, AD 2005, 'Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib', Leukemia, vol. 19, no. 10, pp. 1851-3. https://doi.org/10.1038/sj.leu.2403919

Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib. / Hamzah, H G; Pierce, A; Stewart, W A et al.
In: Leukemia, Vol. 19, No. 10, 10.2005, p. 1851-3.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib

AU - Hamzah, H G

AU - Pierce, A

AU - Stewart, W A

AU - Peter Downes, C

AU - Gray, A

AU - Irvine, A

AU - Spooncer, E

AU - Whetton, A D

PY - 2005/10

Y1 - 2005/10

KW - Antigens, CD34

KW - Benzamides

KW - Chemotactic Factors

KW - Cytokines

KW - Humans

KW - Imatinib Mesylate

KW - Leukemia, Myelogenous, Chronic, BCR-ABL Positive

KW - Lymphocytes

KW - Phosphatidylinositol Phosphates

KW - Piperazines

KW - Pyrimidines

U2 - 10.1038/sj.leu.2403919

DO - 10.1038/sj.leu.2403919

M3 - Article

C2 - 16107888

SN - 0887-6924

VL - 19

SP - 1851

EP - 1853

JO - Leukemia

JF - Leukemia

IS - 10

ER -