Chronic venous leg ulcers: is topical zinc the answer? A review of the literature

Siobhan O'Connor; Siobhan Murphy

doi:10.1097/01.ASW.0000439173.79541.96

Chronic venous leg ulcers: is topical zinc the answer? A review of the literature

Siobhan O'Connor, Siobhan Murphy

Research output: Contribution to journal › Article › peer-review

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Abstract

PURPOSE: To enhance the learner's competence with knowledge of research data on topical zinc for treatment of chronic leg ulcers. TARGET AUDIENCE: This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. OBJECTIVES: After participating in this educational activity, the participant should be better able to: ABSTRACT: Venous leg ulcers (VLUs) are chronic leg wounds that can have a debilitating effect on the physical and psychological health of patients. Older patients, who are a vulnerable group, suffer from VLUs more frequently, and the prevalence of these ulcers increases as the population ages. Venous leg ulcers also pose a serious cost to the healthcare industry. Zinc, in the form of topical creams and lotions, has been used in wound care for more than 3,000 years and is now contained in a variety of wound care products that are used in the treatment of chronic VLUs. OBJECTIVE: The aim of this review was to examine the current empirical evidence to assess if topical zinc-based wound products are effective in promoting the healing of VLUs. METHODS: Following a systematic search and review of the literature, based on selected keywords, 11 studies were identified as being relevant, and data were extracted using content analysis. RESULTS: The results show that there is currently very poor-quality evidence to suggest that topical zinc-based wound products are effective in healing VLUs, either in conjunction with compression therapy, as compression bandages themselves, or as a topical skin protectant. Some of the studies were sponsored by industry, which challenges the validity and reliability of their results. CONCLUSIONS: It is apparent that not only was much of the literature conducted on a small scale, it is also outdated and methodologically inconsistent. There is scant high-quality evidence to suggest that topical zinc-based wound products are effective in promoting the healing of VLUs. New studies are urgently needed that are larger, scientifically rigorous, and without bias from industry. This will enable clinicians to implement evidenced-based practice and choose the most appropriate wound management product to improve patient care and reduce the costs of healthcare

Original language	English
Pages (from-to)	35-44
Number of pages	9
Journal	Advances in Skin and Wound Care
Volume	27
Issue number	1
DOIs	https://doi.org/10.1097/01.ASW.0000439173.79541.96
Publication status	Published - Jan 2014

Keywords

venous leg ulcer
zinc based wound product
chronic wound
zinc

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10.1097/01.ASW.0000439173.79541.96

POST-PEER-REVIEW-NON-PUBLISHERS.PDFAccepted author manuscript, 175 KB

http://www.ncbi.nlm.nih.gov/pubmed/24343392

HARG: Healthy Ageing Research Group
Todd, C. (Researcher), Stanmore, E. (Researcher), Hall, A. (Researcher), Littlewood, A. (Researcher), Davies, A. (Researcher), Sowerbutts, A. M. (Researcher), Maharani, A. (Researcher), Dowding, D. (Researcher), Jones, D. (Researcher), Boulton, L. (Researcher), Cruickshank, F. (Researcher), Hawley-Hague, H. (Researcher), Brooks, J. (Researcher), Griffiths, J. (Researcher), Spencer, K. (Researcher), Fisher, K. (Researcher), Mcgarrigle, L. (Researcher), Cook, M. (Researcher), Pendleton, N. (Researcher), Stanford, P. (Researcher), Lasrado, R. (Researcher), Ahmed, S. (Researcher), Clinch, S. (Researcher), Burden, S. (Researcher), Gluchowski, A. (Researcher), Ford, C. (PGR student), Al Zadjali, F. (PGR student), Sremanakova, J. (PGR student), Fisher, K. (PGR student), Zougar, M. (PGR student), Almohaisen, N. (PGR student), Yang, Y. (PGR student), Mckenzie, Y. (PGR student), O'Connor, S. (Researcher), Aminu, A. (Researcher), Bosco, A. (Researcher), Parchment, A. (Researcher), Money, A. (Researcher), Mackenzie, A. (Researcher), Karki, B. (PGR student), Poku, B. (Researcher), Eost-Telling, C. (Researcher), French, C. (PGR student), Harris, D. (PGR student), Andah, E. (Researcher), Vardy, E. (Researcher), Hakeem, F. (Researcher), Donald, G. (Researcher), Bilsborough, H. (PGR student), Gangannagaripalli, J. (Researcher), Astbury, J. (Researcher), Garsden, J. (Researcher), Ventre, J. (Researcher), Aguilera Munoz, J. (Researcher), Allsopp, K. (Researcher), Mcgarrigle, L. (Researcher), Mott, L. (PGR student), Huang, L. (Researcher), Tomkow, L. (Researcher), Ahmed, N. (Researcher), Fox, S. (Researcher), Mcdermott, J. (Researcher), Hoodless, S. (Researcher), Dlima, S. (PGR student), Shi, Y. (PGR student) & Tang, Y. (PGR student)
Project: Research

Cite this

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title = "Chronic venous leg ulcers: is topical zinc the answer? A review of the literature",

abstract = "PURPOSE: To enhance the learner's competence with knowledge of research data on topical zinc for treatment of chronic leg ulcers. TARGET AUDIENCE: This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. OBJECTIVES: After participating in this educational activity, the participant should be better able to: ABSTRACT: Venous leg ulcers (VLUs) are chronic leg wounds that can have a debilitating effect on the physical and psychological health of patients. Older patients, who are a vulnerable group, suffer from VLUs more frequently, and the prevalence of these ulcers increases as the population ages. Venous leg ulcers also pose a serious cost to the healthcare industry. Zinc, in the form of topical creams and lotions, has been used in wound care for more than 3,000 years and is now contained in a variety of wound care products that are used in the treatment of chronic VLUs. OBJECTIVE: The aim of this review was to examine the current empirical evidence to assess if topical zinc-based wound products are effective in promoting the healing of VLUs. METHODS: Following a systematic search and review of the literature, based on selected keywords, 11 studies were identified as being relevant, and data were extracted using content analysis. RESULTS: The results show that there is currently very poor-quality evidence to suggest that topical zinc-based wound products are effective in healing VLUs, either in conjunction with compression therapy, as compression bandages themselves, or as a topical skin protectant. Some of the studies were sponsored by industry, which challenges the validity and reliability of their results. CONCLUSIONS: It is apparent that not only was much of the literature conducted on a small scale, it is also outdated and methodologically inconsistent. There is scant high-quality evidence to suggest that topical zinc-based wound products are effective in promoting the healing of VLUs. New studies are urgently needed that are larger, scientifically rigorous, and without bias from industry. This will enable clinicians to implement evidenced-based practice and choose the most appropriate wound management product to improve patient care and reduce the costs of healthcare",

keywords = "venous leg ulcer, zinc based wound product, chronic wound, zinc",

author = "Siobhan O'Connor and Siobhan Murphy",

year = "2014",

month = jan,

doi = "10.1097/01.ASW.0000439173.79541.96",

language = "English",

volume = "27",

pages = "35--44",

journal = "Advances in Skin and Wound Care",

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T1 - Chronic venous leg ulcers: is topical zinc the answer? A review of the literature

AU - O'Connor, Siobhan

AU - Murphy, Siobhan

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N2 - PURPOSE: To enhance the learner's competence with knowledge of research data on topical zinc for treatment of chronic leg ulcers. TARGET AUDIENCE: This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. OBJECTIVES: After participating in this educational activity, the participant should be better able to: ABSTRACT: Venous leg ulcers (VLUs) are chronic leg wounds that can have a debilitating effect on the physical and psychological health of patients. Older patients, who are a vulnerable group, suffer from VLUs more frequently, and the prevalence of these ulcers increases as the population ages. Venous leg ulcers also pose a serious cost to the healthcare industry. Zinc, in the form of topical creams and lotions, has been used in wound care for more than 3,000 years and is now contained in a variety of wound care products that are used in the treatment of chronic VLUs. OBJECTIVE: The aim of this review was to examine the current empirical evidence to assess if topical zinc-based wound products are effective in promoting the healing of VLUs. METHODS: Following a systematic search and review of the literature, based on selected keywords, 11 studies were identified as being relevant, and data were extracted using content analysis. RESULTS: The results show that there is currently very poor-quality evidence to suggest that topical zinc-based wound products are effective in healing VLUs, either in conjunction with compression therapy, as compression bandages themselves, or as a topical skin protectant. Some of the studies were sponsored by industry, which challenges the validity and reliability of their results. CONCLUSIONS: It is apparent that not only was much of the literature conducted on a small scale, it is also outdated and methodologically inconsistent. There is scant high-quality evidence to suggest that topical zinc-based wound products are effective in promoting the healing of VLUs. New studies are urgently needed that are larger, scientifically rigorous, and without bias from industry. This will enable clinicians to implement evidenced-based practice and choose the most appropriate wound management product to improve patient care and reduce the costs of healthcare

AB - PURPOSE: To enhance the learner's competence with knowledge of research data on topical zinc for treatment of chronic leg ulcers. TARGET AUDIENCE: This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. OBJECTIVES: After participating in this educational activity, the participant should be better able to: ABSTRACT: Venous leg ulcers (VLUs) are chronic leg wounds that can have a debilitating effect on the physical and psychological health of patients. Older patients, who are a vulnerable group, suffer from VLUs more frequently, and the prevalence of these ulcers increases as the population ages. Venous leg ulcers also pose a serious cost to the healthcare industry. Zinc, in the form of topical creams and lotions, has been used in wound care for more than 3,000 years and is now contained in a variety of wound care products that are used in the treatment of chronic VLUs. OBJECTIVE: The aim of this review was to examine the current empirical evidence to assess if topical zinc-based wound products are effective in promoting the healing of VLUs. METHODS: Following a systematic search and review of the literature, based on selected keywords, 11 studies were identified as being relevant, and data were extracted using content analysis. RESULTS: The results show that there is currently very poor-quality evidence to suggest that topical zinc-based wound products are effective in healing VLUs, either in conjunction with compression therapy, as compression bandages themselves, or as a topical skin protectant. Some of the studies were sponsored by industry, which challenges the validity and reliability of their results. CONCLUSIONS: It is apparent that not only was much of the literature conducted on a small scale, it is also outdated and methodologically inconsistent. There is scant high-quality evidence to suggest that topical zinc-based wound products are effective in promoting the healing of VLUs. New studies are urgently needed that are larger, scientifically rigorous, and without bias from industry. This will enable clinicians to implement evidenced-based practice and choose the most appropriate wound management product to improve patient care and reduce the costs of healthcare

KW - venous leg ulcer

KW - zinc based wound product

KW - chronic wound

KW - zinc

U2 - 10.1097/01.ASW.0000439173.79541.96

DO - 10.1097/01.ASW.0000439173.79541.96

M3 - Article

SN - 1527-7941

VL - 27

SP - 35

EP - 44

JO - Advances in Skin and Wound Care

JF - Advances in Skin and Wound Care

IS - 1

ER -

Chronic venous leg ulcers: is topical zinc the answer? A review of the literature

Abstract

Keywords

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HARG: Healthy Ageing Research Group

Cite this