Circadian changes of type II adenylyl cyclase mRNA in the rat suprachiasmatic nuclei

Felino Ramon A Cagampang, Ferenc A. Antoni, Susan M. Smith, Hugh D. Piggins, Clive W. Coen

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Circadian functions of the suprachiasmatic nuclei (SCN) are influenced by cyclic AMP (cAMP). Adenylyl cyclase type II (AC-II) is a cAMP-generating enzyme which, in the context of activation by G(sα), is further stimulated by protein kinase C or G protein βγ subunits. Using in situ hybridization we have found a biphasic variation in AC-II mRNA within the rat SCN during the light-dark cycle (peaks at Zeitgeber time 6 and 18) and also in constant darkness (peaks at circadian time 2 and 14). The cingulate cortex showed no such variation. These findings suggest that circadian changes in AC-II expression may be pertinent to the rhythmic functions of the SCN.
    Original languageEnglish
    Pages (from-to)279-282
    Number of pages3
    JournalBrain research
    Volume810
    Issue number1-2
    DOIs
    Publication statusPublished - 9 Nov 1998

    Keywords

    • Adenylyl cyclase
    • Circadian rhythm
    • Cyclic AMP
    • In situ hybridization histochemistry
    • Suprachiasmatic nuclei

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