Circadian regulation of pulmonary disease: the importance of timing

Peter Cunningham, Callum Jackson, Amlan Chakraborty, Jafar Cain, Hannah Durrington, John Blaikley

Research output: Contribution to journalReview articlepeer-review

Abstract

Circadian regulation causes the activity of biological processes to vary over a 24-h cycle. The pathological effects of this variation are predominantly studied using two different approaches: pre-clinical models or observational clinical studies. Both these approaches have provided useful insights into how underlying circadian mechanisms operate and specifically which are regulated by the molecular oscillator, a key time-keeping mechanism in the body. This review compares and contrasts findings from these two approaches in the context of four common respiratory diseases (asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and respiratory infection). Potential methods used to identify and measure human circadian oscillations are also discussed as these will be useful outcome measures in future interventional human trials that target circadian mechanisms.

Original languageEnglish
Pages (from-to)895-912
Number of pages18
JournalClin Sci (Lond).
Volume137
Issue number11
DOIs
Publication statusPublished - 14 Jun 2023

Keywords

  • Lung
  • Asthma
  • Chronic Obstructive Pulmonary Disease
  • Circadian clock
  • Infection
  • Pulmonary Fibrosis

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