Circulating insulin-like growth factor-binding protein 3 levels, independent of insulin-like growth factor 1, associate with truncal fat and systolic blood pressure in south asian and white european preschool children

Leena Patel, Andrew Whatmore, Jill Davies, Narinder Bansal, Avni Vyas, Isla Gemmell, John Oldroyd, J. Kennedy Cruickshank, Peter Clayton

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Aims: To study the effect of the insulin-like growth factor (IGF) system on growth, adiposity and systolic blood pressure (SBP) in early life in British-born South Asian (SA) and White European (WE) children. Methods: The effect of IGF-1 and insulin-like growth factor-binding protein 3 (IGFBP-3) over the first 4 years in 204 healthy SA and WE children was investigated by mixed linear regression modelling. This enabled inclusion of all follow-up observations and adjustment for repeated measures. Results: At birth, SA babies were shorter and lighter than WE babies. Over 4 years, SA ethnicity was associated with lower height, weight and body mass index (BMI) standard deviation score (SDS), higher subscapular/triceps skinfold thickness (Ss/Tr SFT) and lower SBP (all p <0.01). IGF-1 was associated with greater height (p = 0.03), weight (p <0.001) and BMI SDS (p <0.001), and IGFBP-3 with greater weight SDS (p <0.001), BMI SDS (p = 0.001), Ss/Tr SFT (p = 0.003) and SBP (p = 0.023). Conclusions: Over this first 4-year period of life, SA ethnicity was associated with being shorter, lighter, having more superficial truncal adiposity and lower SBP. IGFBP-3 (and not IGF-1) was independently associated with both superficial truncal adiposity and SBP, suggesting that IGFBP-3 is a potential metabolic and cardiovascular marker in healthy children in the early years of life. © 2013 S. Karger AG, Basel.
    Original languageEnglish
    Pages (from-to)109-117
    Number of pages8
    JournalHormone research in paediatrics
    Volume81
    Issue number2
    DOIs
    Publication statusPublished - 2014

    Keywords

    • Ethnicity
    • Insulin-like growth factor 1
    • Insulin-like growth factor-binding protein 3
    • Systolic blood pressure
    • Truncal fat

    Fingerprint

    Dive into the research topics of 'Circulating insulin-like growth factor-binding protein 3 levels, independent of insulin-like growth factor 1, associate with truncal fat and systolic blood pressure in south asian and white european preschool children'. Together they form a unique fingerprint.

    Cite this