Circulating levels of clusterin and complement factor H in patients with obstructive sleep apnea

Martina Meszaros, Peter Horvath, Adrian Kis, Laszlo Kunos, Adam D Tarnoki, David L Tarnoki, Zsofia Lazar, Andras Bikov

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: Obstructive sleep apnea (OSA) activates the complement system; however, the levels of membrane attack complex (MAC) are unaltered suggesting regulatory mechanisms. Our aim was to investigate complement factor H (CFH) and clusterin, two important complement regulators in OSA.

Materials & methods: We analyzed clusterin and CFH levels in plasma of 86 patients with OSA and 33 control subjects.

Results: There was no difference in CFH levels between patients (1099.4/784.6–1570.5/μg/ml) and controls (1051.4/652.0–1615.1/μg/ml, p = 0.72). Clusterin levels were higher in patients with OSA (309.7/217.2–763.2/μg/ml vs 276.1/131.0–424.3/μg/ml, p = 0.048) with a trend for a positive correlation with disease severity (p = 0.073).

Conclusion: Increase in clusterin levels may be protective in OSA by blocking the MAC formation.
Original languageEnglish
Pages (from-to)323-330
Number of pages8
JournalBiomarkers in Medicine
Volume15
Issue number5
Early online date5 Mar 2021
DOIs
Publication statusPublished - Apr 2021

Keywords

  • complement system
  • inflammation
  • OSA
  • sleep apnea

Fingerprint

Dive into the research topics of 'Circulating levels of clusterin and complement factor H in patients with obstructive sleep apnea'. Together they form a unique fingerprint.

Cite this