Circulating microRNAs -192 and -194 are associated with the presence and incidence of diabetes mellitus

Andrea Jaeger, Lukas Zollinger, Christoph H. Saely, Axel Muendlein, Ioannis Evangelakos, Dimitris Nasias, Nikoleta Charizopoulou, Jonathan D. Schofield, Alaa Othman, Handrean Soran, Dimitris Kardassis, Heinz Drexel, Arnold Von Eckardstein

Research output: Contribution to journalArticlepeer-review

Abstract

We sought to identify circulating microRNAs as biomarkers of prevalent or incident diabetes. In a pilot study of 18 sex- and age-matched patients with metabolic syndrome, nine of whom developed diabetes during 6 years of follow-up, an array of 372 microRNAs discovered significantly elevated serum levels of microRNAs -122, -192, -194, and -215 in patients who developed diabetes mellitus type 2 (T2DM). In two cross-sectional validation studies, one encompassing sex- and age-matched groups of patients with T2DM, impaired fasting glucose (IFG) and euglycemic controls (n = 43 each) and the other 53 patients with type 1 diabetes and 54 age- and BMI-matched euglycemic controls, serum levels of miR-192, miR-194, and mi215 were significantly higher in diabetic subjects than in probands with euglycemia or IFG. In a longitudinal study of 213 initially diabetes-free patients of whom 35 developed diabetes during 6 years of follow-up, elevated serum levels of microRNAs 192 and 194 were associated with incident T2DM, independently of fasting glucose, HbA1c and other risk factors. Serum levels of miR-192 and miR-194 were also elevated in diabetic Akt2 knockout mice compared to wild type mice. In conclusion, circulating microRNAs -192 and -194 are potential biomarkers for risk of diabetes.
Original languageEnglish
Article number14274
JournalScientific Reports
Volume8
Issue number1
Early online date24 Sept 2018
DOIs
Publication statusPublished - 2018

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