@article{0fd7fcf7a6e140708bbe6f636ce1f95a,
title = "Circulating survivin levels in healthy and asthmatic pregnancy",
abstract = "Background: Asthma is one of the most common conditions which complicate pregnancy. Pro- and anti-apoptotic mechanisms can be modulated by asthma accompanying pregnancy. Survivin, an anti-apoptotic protein has been implicated in the pathomechanism of asthma and also in the development of pathological pregnancies; however survivin has not been studied in pregnant asthmatics.Methods: Twenty-eight asthmatic pregnant (AP), 25 asthmatic non-pregnant (ANP), 21 healthy pregnant (HP) and 29 healthy non-pregnant (HNP) women were enrolled in this cross-sectional study. Plasma survivin concentration was determined by ELISA.Results: Plasma survivin was significantly lower in HP (1.64 /0-74.9/ pg/ml) than in HNP (24.6 /0-333.3/ pg/ml, p = 0.01). However, this difference was not observed between the asthmatic groups (p = 0.64). Similarly, there was no difference either between HNP and ANP (10.5 /0-215.4/ pg/ml, p = 0.23) or between HP and AP (13.9 /0-364.1/ pg/ml, p = 0.30) groups.Conclusions: Decreased plasma survivin levels in physiological but not in asthmatic pregnancy may suggest that the normal apoptotic mechanisms are compromised in asthmatic gestation. {\textcopyright} 2014 Bikov et al.; licensee BioMed Central Ltd.",
keywords = "Apoptosis, Asthma, Pregnancy, Survivin, survivin, BIRC5 protein, human, inhibitor of apoptosis protein, adult, Article, asthma, blood sampling, clinical article, controlled study, cross-sectional study, enzyme linked immunosorbent assay, female, human, pathophysiology, pregnancy, pregnant woman, apoptosis, blood, down regulation, Hungary, immunology, metabolism, outpatient department, pregnancy complication, second trimester pregnancy, teaching hospital, third trimester pregnancy, Adult, Cross-Sectional Studies, Down-Regulation, Enzyme-Linked Immunosorbent Assay, Female, Hospitals, Teaching, Humans, Inhibitor of Apoptosis Proteins, Outpatient Clinics, Hospital, Pregnancy Complications, Pregnancy Trimester, Second, Pregnancy Trimester, Third",
author = "A. Bikov and R. Bocskei and N. Eszes and A. Bohacs and G. Losonczy and J. Rigo and I. Horvath and L. Tamasi",
note = "Cited By :1 Export Date: 31 October 2018 Correspondence Address: Bikov, A.; Department of Pulmonology, Semmelweis University, 1/C Dios arok, Hungary Chemicals/CAS: survivin, 195263-98-0; BIRC5 protein, human; Inhibitor of Apoptosis Proteins References: Tamasi, L., Somoskovi, A., Muller, V., Bartfai, Z., Acs, N., Puho, E., Czeizel, A.E., A population-based case-control study on the effect of bronchial asthma during pregnancy for congenital abnormalities of the offspring (2006) J Asthma, 43, pp. 81-86. , 16448971; Dombrowski, M.P., Asthma and pregnancy (2006) Obstet Gynecol, 108, pp. 667-681. , 16946229; Maselli, D.J., Adams, S.G., Peters, J.I., Levine, S.M., Management of asthma during pregnancy (2013) Ther Adv Respir Dis, 7, pp. 87-100. , 23129568; Frangsmyr, L., Baranov, V., Nagaeva, O., Stendahl, U., Kjellberg, L., Mincheva-Nilsson, L., Cytoplasmic microvesicular form of Fas ligand in human early placenta: switching the tissue immune privilege hypothesis from cellular to vesicular level (2005) Mol Hum Reprod, 11, pp. 35-41; Taylor, D.D., Sullivan, S.A., Eblen, A.C., Gercel-Taylor, C., Modulation of T-cell CD3-zeta chain expression during normal pregnancy (2002) J Reprod Immunol, 54, pp. 15-31. , 11839393; Redman, C.W., Sargent, I.L., Circulating microparticles in normal pregnancy and pre-eclampsia (2008) Placenta, 29 (A), pp. S73-S77; Bohacs, A., Pallinger, E., Tamasi, L., Rigo, J., Komlosi, Z., Muller, V., Dong, Y., Losonczy, G., Surface markers of lymphocyte activation in pregnant asthmatics (2010) Inflamm Res, 59, pp. 63-70. , 2803259, 19714295; Tamasi, L., Bohacs, A., Tamasi, V., Stenczer, B., Prohaszka, Z., Rigo, J., Losonczy, G., Molvarec, A., Increased circulating heat shock protein 70 levels in pregnant asthmatics (2010) Cell Stress Chaperones, 15, pp. 295-300. , 2866990, 19777374; Cheung, C.H., Huang, C.C., Tsai, F.Y., Lee, J.Y., Cheng, S.M., Chang, Y.C., Huang, Y.C., Chang, J.Y., Survivin - biology and potential as a therapeutic target in oncology (2013) Onco Targets Ther, 6, pp. 1453-1462. , 3804542, 24204160; Shiozaki, A., Kataoka, K., Fujimura, M., Yuki, H., Sakai, M., Saito, S., Survivin inhibits apoptosis in cytotrophoblasts (2003) Placenta, 24, pp. 65-76. , 12495661; Muschol-Steinmetz, C., Friemel, A., Kreis, N.N., Reinhard, J., Yuan, J., Louwen, F., Function of survivin in trophoblastic cells of the placenta (2013) PLoS One, 8, p. e73337. , 3778024, 24069188; Adida, C., Berrebi, D., Peuchmaur, M., Reyes-Mugica, M., Altieri, D.C., Anti-apoptosis gene, survivin, and prognosis of neuroblastoma (1998) Lancet, 351, pp. 882-883. , 9525374; Zimmerman, M., Yang, D., Hu, X., Liu, F., Singh, N., Browning, D., Ganapathy, V., Liu, K., IFN-gamma upregulates survivin and Ifi202 expression to induce survival and proliferation of tumor-specific T cells (2010) PLoS One, 5, p. e14076. , 2989915, 21124930; Lehner, R., Bobak, J., Kim, N.W., Shroyer, A.L., Shroyer, K.R., Localization of telomerase hTERT protein and survivin in placenta: relation to placental development and hydatidiform mole (2001) Obstet Gynecol, 97, pp. 965-970. , 11384704; Li, C.F., Gou, W.L., Li, X.L., Wang, S.L., Yang, T., Chen, Q., Reduced expression of survivin, the inhibitor of apoptosis protein correlates with severity of preeclampsia (2012) Placenta, 33, pp. 47-51. , 22033156; Jutzy, J.M., Khan, S., Asuncion-Valenzuela, M.M., Milford, T.A., Payne, K.J., Wall, N.R., Tumor-released survivin induces a type-2 t cell response and decreases cytotoxic T cell function, in vitro (2013) Cancer Microenviron, 6, pp. 57-68. , 3601219, 22322461; Ungvari, I., Hullam, G., Antal, P., Kiszel, P.S., Gezsi, A., Hadadi, E., Virag, V., Szalai, C., Evaluation of a partial genome screening of two asthma susceptibility regions using bayesian network based bayesian multilevel analysis of relevance (2012) PLoS One, 7, p. e33573. , 3303848, 22432035; Tumes, D.J., Connolly, A., Dent, L.A., Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma (2009) Int Immunol, 21, pp. 633-644. , 19395375; Ungvari, I., Hadadi, E., Virag, V., Bikov, A., Nagy, A., Semsei, A.F., Galffy, G., Szalai, C., Implication of BIRC5 in asthma pathogenesis (2012) Int Immunol, 24, pp. 293-301. , 22336533; Sugahara, K., Uemura, A., Harasawa, H., Nagai, H., Hirakata, Y., Tomonaga, M., Murata, K., Kamihira, S., Clinical relevance of survivin as a biomarker in neoplasms, especially in adult T-cell leukemias and acute leukemias (2004) Int J Hematol, 80, pp. 52-58. , 15293568; Yang, M., Liu, Y., Lu, S., Wang, Z., Wang, R., Zi, Y., Li, J., Analysis of the expression levels of survivin and VEGF in patients with acute lymphoblastic leukemia (2013) Exp Ther Med, 5, pp. 305-307. , 3524107, 23251288; El-Attar, H.A., Kandil, M.H., El-Kerm, Y.M., El-Ghandour, M.K., Comparison of serum survivin and alpha fetoprotein in Egyptian patients with hepatocellular carcinoma associated with hepatitis C viral infection (2010) Asian Pac J Cancer Prev, 11, pp. 897-903; Bokarewa, M., Lindblad, S., Bokarew, D., Tarkowski, A., Balance between survivin, a key member of the apoptosis inhibitor family, and its specific antibodies determines erosivity in rheumatoid arthritis (2005) Arthritis Res Ther, 7, pp. R349-R358. , 1065333, 15743483; ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005 (2005) Am J Respir Crit Care Med, 171, pp. 912-930; Nathan, R.A., Sorkness, C.A., Kosinski, M., Schatz, M., Li, J.T., Marcus, P., Murray, J.J., Pendergraft, T.B., Development of the asthma control test: a survey for assessing asthma control (2004) J Allergy Clin Immunol, 113, pp. 59-65. , 14713908; Faul, F., Erdfelder, E., Buchner, A., Lang, A.G., Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses (2009) Behav Res Methods, 41, pp. 1149-1160. , 19897823; Khan, S., Aspe, J.R., Asumen, M.G., Almaguel, F., Odumosu, O., Acevedo-Martinez, S., De Leon, M., Wall, N.R., Extracellular, cell-permeable survivin inhibits apoptosis while promoting proliferative and metastatic potential (2009) Br J Cancer, 100, pp. 1073-1086. , 2669990, 19293795; Toldi, G., Molvarec, A., Stenczer, B., Muller, V., Eszes, N., Bohacs, A., Bikov, A., Tamasi, L., Peripheral T(h)1/T(h)2/T(h)17/regulatory T-cell balance in asthmatic pregnancy (2011) Int Immunol, 23, pp. 669-677. , 21937455; Molvarec, A., Szarka, A., Walentin, S., Beko, G., Karadi, I., Prohaszka, Z., Rigo, J., Serum leptin levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in normal pregnancy and preeclampsia (2011) Reprod Biol Endocrinol, 9, p. 124. , 3184629, 21906313; Bikov, A., Bohacs, A., Eszes, N., Weiszhar, Z., Ivancso, I., Muller, V., Rigo, J., Horvath, I., Circulating and exhaled vascular endothelial growth factor in asthmatic pregnancy (2012) Biomarkers, 17, pp. 648-654. , 22900522; Beierle, E.A., Nagaram, A., Dai, W., Iyengar, M., Chen, M.K., VEGF-mediated survivin expression in neuroblastoma cells (2005) J Surg Res, 127, pp. 21-28. , 15882878; Formby, B., Wiley, T.S., Bcl-2, survivin and variant CD44 v7-v10 are downregulated and p53 is upregulated in breast cancer cells by progesterone: inhibition of cell growth and induction of apoptosis (1999) Mol Cell Biochem, 202, pp. 53-61. , 10705995; Tamasi, L., Bohacs, A., Pallinger, E., Falus, A., Rigo, J., Muller, V., Komlosi, Z., Losonczy, G., Increased interferon-gamma- and interleukin-4-synthesizing subsets of circulating T lymphocytes in pregnant asthmatics (2005) Clin Exp Allergy, 35, pp. 1197-1203. , 16164448; Beere, H.M., Wolf, B.B., Cain, K., Mosser, D.D., Mahboubi, A., Kuwana, T., Tailor, P., Green, D.R., Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome (2000) Nat Cell Biol, 2, pp. 469-475. , 10934466; Molvarec, A., Tamasi, L., Losonczy, G., Madach, K., Prohaszka, Z., Rigo, J., Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancies (2010) Cell Stress Chaperones, 15, pp. 237-247. , 2866993, 19821156",
year = "2014",
doi = "10.1186/1477-7827-12-93",
language = "English",
volume = "12",
journal = "Reproductive Biology and Endocrinology",
issn = "1477-7827",
publisher = "Springer Nature",
number = "1",
}
