Citalopram modulation of neuronal responses to aversive face emotions: A functional MRI study

Ian M. Anderson; Cristina M. Del-Ben; Shane McKie; Paul Richardson; Stephen R. Williams; Rebecca Elliott; J. F. William Deakin

doi:10.1097/WNR.0b013e3282742115

Citalopram modulation of neuronal responses to aversive face emotions: A functional MRI study

Ian M. Anderson, Cristina M. Del-Ben, Shane McKie, Paul Richardson, Stephen R. Williams, Rebecca Elliott, J. F. William Deakin

Research output: Contribution to journal › Article › peer-review

Abstract

This study investigated the serotonergic modulation of face emotion processing using blood oxygen level-dependent (BOLD) functional MRI. In a placebo-controlled, balanced order design, intravenous citalopram (7.5 mg) was given to 12 male volunteers 60 min before a covert face emotion recognition task. Angry, disgusted and fearful faces produced BOLD signal responses, which were broadly consistent with previous findings. Citalopram enhanced the BOLD signal response in the left posterior insula (together with nonprespecified pulvinar and visual cortex) but attenuated activation in the left amygdala to disgusted faces and right amygdala activation to fearful faces. No citalopram modulation of BOLD responses to angry faces were found. These results suggest that serotonin modulates low-level amygdala activation to aversive stimuli. © 2007 Lippincott Williams & Wilkins, Inc.

Original language	English
Pages (from-to)	1351-1355
Number of pages	4
Journal	NeuroReport
Volume	18
Issue number	13
DOIs	https://doi.org/10.1097/WNR.0b013e3282742115
Publication status	Published - Aug 2007

Keywords

Citalopram
Emotional processing
Face emotion
Functional MRI
Neuroimaging
Selective serotonin reuptake inhibitors serotonin

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10.1097/WNR.0b013e3282742115

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title = "Citalopram modulation of neuronal responses to aversive face emotions: A functional MRI study",

abstract = "This study investigated the serotonergic modulation of face emotion processing using blood oxygen level-dependent (BOLD) functional MRI. In a placebo-controlled, balanced order design, intravenous citalopram (7.5 mg) was given to 12 male volunteers 60 min before a covert face emotion recognition task. Angry, disgusted and fearful faces produced BOLD signal responses, which were broadly consistent with previous findings. Citalopram enhanced the BOLD signal response in the left posterior insula (together with nonprespecified pulvinar and visual cortex) but attenuated activation in the left amygdala to disgusted faces and right amygdala activation to fearful faces. No citalopram modulation of BOLD responses to angry faces were found. These results suggest that serotonin modulates low-level amygdala activation to aversive stimuli. {\textcopyright} 2007 Lippincott Williams & Wilkins, Inc.",

keywords = "Citalopram, Emotional processing, Face emotion, Functional MRI, Neuroimaging, Selective serotonin reuptake inhibitors serotonin",

author = "Anderson, {Ian M.} and Del-Ben, {Cristina M.} and Shane McKie and Paul Richardson and Williams, {Stephen R.} and Rebecca Elliott and {William Deakin}, {J. F.}",

year = "2007",

month = aug,

doi = "10.1097/WNR.0b013e3282742115",

language = "English",

volume = "18",

pages = "1351--1355",

journal = "NeuroReport",

publisher = "Lippincott Williams & Wilkins",

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TY - JOUR

T1 - Citalopram modulation of neuronal responses to aversive face emotions: A functional MRI study

AU - Anderson, Ian M.

AU - Del-Ben, Cristina M.

AU - McKie, Shane

AU - Richardson, Paul

AU - Williams, Stephen R.

AU - Elliott, Rebecca

AU - William Deakin, J. F.

PY - 2007/8

Y1 - 2007/8

N2 - This study investigated the serotonergic modulation of face emotion processing using blood oxygen level-dependent (BOLD) functional MRI. In a placebo-controlled, balanced order design, intravenous citalopram (7.5 mg) was given to 12 male volunteers 60 min before a covert face emotion recognition task. Angry, disgusted and fearful faces produced BOLD signal responses, which were broadly consistent with previous findings. Citalopram enhanced the BOLD signal response in the left posterior insula (together with nonprespecified pulvinar and visual cortex) but attenuated activation in the left amygdala to disgusted faces and right amygdala activation to fearful faces. No citalopram modulation of BOLD responses to angry faces were found. These results suggest that serotonin modulates low-level amygdala activation to aversive stimuli. © 2007 Lippincott Williams & Wilkins, Inc.

AB - This study investigated the serotonergic modulation of face emotion processing using blood oxygen level-dependent (BOLD) functional MRI. In a placebo-controlled, balanced order design, intravenous citalopram (7.5 mg) was given to 12 male volunteers 60 min before a covert face emotion recognition task. Angry, disgusted and fearful faces produced BOLD signal responses, which were broadly consistent with previous findings. Citalopram enhanced the BOLD signal response in the left posterior insula (together with nonprespecified pulvinar and visual cortex) but attenuated activation in the left amygdala to disgusted faces and right amygdala activation to fearful faces. No citalopram modulation of BOLD responses to angry faces were found. These results suggest that serotonin modulates low-level amygdala activation to aversive stimuli. © 2007 Lippincott Williams & Wilkins, Inc.

KW - Citalopram

KW - Emotional processing

KW - Face emotion

KW - Functional MRI

KW - Neuroimaging

KW - Selective serotonin reuptake inhibitors serotonin

U2 - 10.1097/WNR.0b013e3282742115

DO - 10.1097/WNR.0b013e3282742115

M3 - Article

C2 - 17762711

VL - 18

SP - 1351

EP - 1355

JO - NeuroReport

JF - NeuroReport

IS - 13

ER -

Citalopram modulation of neuronal responses to aversive face emotions: A functional MRI study

Abstract

Keywords

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