@article{e2adfdc64af34c728f22a4ba519fb888,
title = "Cleft lip and palate: Understanding genetic and environmental influences",
abstract = "Clefts of the lip and/or palate (CLP) are common birth defects of complex aetiology. CLP can occur in isolation or as part of a broad range of chromosomal, Mendelian or teratogenic syndromes. Although there has been marked progress in identifying genetic and environmental triggers for syndromic CLP, the aetiology of the more common non-syndromic (isolated) forms remains poorly characterized. Recently, using a combination of epidemiology, careful phenotyping, genome-wide association studies and analysis of animal models, several distinct genetic and environmental risk factors have been identified and confirmed for non-syndromic CLP. These findings have advanced our understanding of developmental biology and created new opportunities for clinical translational research. {\textcopyright} 2011 Macmillan Publishers Limited. All rights reserved.",
author = "Dixon, {Michael J.} and Marazita, {Mary L.} and Beaty, {Terri H.} and Murray, {Jeffrey C.}",
note = "082,868, Wellcome Trust, United KingdomG0901539, Medical Research Council, United KingdomP50 DE016215-04, NIDCR NIH HHS, United StatesP50 DE016215-05, NIDCR NIH HHS, United StatesP50-DE016215, NIDCR NIH HHS, United StatesR01 DE012472-02, NIDCR NIH HHS, United StatesR01 DE012472-03, NIDCR NIH HHS, United StatesR01 DE014581-07, NIDCR NIH HHS, United StatesR01 DE014581-08, NIDCR NIH HHS, United StatesR01 DE016148-06, NIDCR NIH HHS, United StatesR01 DE016148-07, NIDCR NIH HHS, United StatesR01-DE014581, NIDCR NIH HHS, United StatesR01-DE016148, NIDCR NIH HHS, United StatesR01-DE08559, NIDCR NIH HHS, United StatesR37 DE008559-19, NIDCR NIH HHS, United StatesR37 DE008559-20, NIDCR NIH HHS, United StatesR37 DE008559-21, NIDCR NIH HHS, United StatesR37 DE008559-22, NIDCR NIH HHS, United StatesU01 DE018993-01, NIDCR NIH HHS, United StatesU01 DE018993-02, NIDCR NIH HHS, United StatesU01 DE020057-02, NIDCR NIH HHS, United StatesU01 DE020057-03, NIDCR NIH HHS, United StatesU01-DE018993, NIDCR NIH HHS, United StatesU01-DE20057, NIDCR NIH HHS, United States",
year = "2011",
month = mar,
doi = "10.1038/nrg2933",
language = "English",
volume = "12",
pages = "167--178",
journal = "Nature Reviews Genetics",
issn = "1471-0056",
publisher = "Nature Research",
number = "3",
}