TY - JOUR
T1 - Clinical and genomic characterisation of adenoid cystic carcinoma of the head and neck, lung, and breast
AU - Heathcote, Emily
AU - Patel, Karan
AU - Rack, Samuel
AU - Hodgson, Clare
AU - Mistry, Hitesh
AU - Betts, Guy
AU - Bishop, Paul
AU - Hall, Rachel
AU - Armstrong, Anne
AU - Harrington, Kevin J
AU - Metcalf, Robert
PY - 2023/6
Y1 - 2023/6
N2 - Lay abstract: In this presentation we reported a study on 450 ACC patients in the UK to understand the disease better. We collected clinical and genomic data from the patients and analyzed their outcomes. The majority of ACC cases (44.7%) originated from the major salivary glands, followed by other sites like sinonasal (22.0%), upper aerodigestive (15.3%), and tracheobronchial (10.2%). Recurrent or metastatic disease was confirmed in 69.8% of patients. The median time to first confirmed recurrence (TTFR) was 4.5 years, and the median overall survival from recurrence (OS-rec) was 4.8 years. Major salivary ACC had the longest TTFR (5.8 years), while tracheobronchial and sinonasal ACC had significantly shorter TTFR. Breast ACC had a similar overall survival from diagnosis (OS-diag) compared to major salivary ACC but showed increased TTFR and shorter OS-rec. This study suggests the need for different follow-up protocols and systemic therapy strategies may be needed for ACC of different primary sites.In this presentation we reported a study on 450 ACC patients in the UK to understand the disease better. We collected clinical and genomic data from the patients and analyzed their outcomes. The majority of ACC cases (44.7%) originated from the major salivary glands, followed by other sites like sinonasal (22.0%), upper aerodigestive (15.3%), and tracheobronchial (10.2%). Recurrent or metastatic disease was confirmed in 69.8% of patients. The median time to first confirmed recurrence (TTFR) was 4.5 years, and the median overall survival from recurrence (OS-rec) was 4.8 years. Major salivary ACC had the longest TTFR (5.8 years), while tracheobronchial and sinonasal ACC had significantly shorter TTFR. Breast ACC had a similar overall survival from diagnosis (OS-diag) compared to major salivary ACC but showed increased TTFR and shorter OS-rec. This study suggests the need for different follow-up protocols and systemic therapy strategies may be needed for ACC of different primary sites.
AB - Lay abstract: In this presentation we reported a study on 450 ACC patients in the UK to understand the disease better. We collected clinical and genomic data from the patients and analyzed their outcomes. The majority of ACC cases (44.7%) originated from the major salivary glands, followed by other sites like sinonasal (22.0%), upper aerodigestive (15.3%), and tracheobronchial (10.2%). Recurrent or metastatic disease was confirmed in 69.8% of patients. The median time to first confirmed recurrence (TTFR) was 4.5 years, and the median overall survival from recurrence (OS-rec) was 4.8 years. Major salivary ACC had the longest TTFR (5.8 years), while tracheobronchial and sinonasal ACC had significantly shorter TTFR. Breast ACC had a similar overall survival from diagnosis (OS-diag) compared to major salivary ACC but showed increased TTFR and shorter OS-rec. This study suggests the need for different follow-up protocols and systemic therapy strategies may be needed for ACC of different primary sites.In this presentation we reported a study on 450 ACC patients in the UK to understand the disease better. We collected clinical and genomic data from the patients and analyzed their outcomes. The majority of ACC cases (44.7%) originated from the major salivary glands, followed by other sites like sinonasal (22.0%), upper aerodigestive (15.3%), and tracheobronchial (10.2%). Recurrent or metastatic disease was confirmed in 69.8% of patients. The median time to first confirmed recurrence (TTFR) was 4.5 years, and the median overall survival from recurrence (OS-rec) was 4.8 years. Major salivary ACC had the longest TTFR (5.8 years), while tracheobronchial and sinonasal ACC had significantly shorter TTFR. Breast ACC had a similar overall survival from diagnosis (OS-diag) compared to major salivary ACC but showed increased TTFR and shorter OS-rec. This study suggests the need for different follow-up protocols and systemic therapy strategies may be needed for ACC of different primary sites.
M3 - Meeting Abstract
SN - 0732-183X
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
M1 - abst 6094
ER -
