Clinical prediction in early pregnancy of infants small for gestational age by customised birthweight centiles: findings from a healthy nulliparous cohort

L M McCowan; J M Thompson; R S Taylor; R A North; L Poston; P N Baker; J Myers; C T Roberts; G A Dekker; N A Simpson; J J Walker; L C Kenny

doi:10.1371/journal.pone.0070917

Clinical prediction in early pregnancy of infants small for gestational age by customised birthweight centiles: findings from a healthy nulliparous cohort

L M McCowan
, J M Thompson
, R S Taylor
, R A North
, L Poston
, P N Baker
, J Myers
, C T Roberts
, G A Dekker
, N A Simpson
, J J Walker
, L C Kenny

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: Small for gestational age (SGA) infants comprise up to 50% of all stillbirths and a minority are detected before birth. We aimed to develop and validate early pregnancy predictive models for SGA infants. METHODS: 5628 participants from SCOPE, a prospective study of nulliparous pregnant women, were interviewed at 15 +/- 1 weeks' gestation. Fetal anthropometry, uterine and umbilical Doppler studies were performed at 20 +/- 1 weeks'. The cohort was divided into training (n = 3735) and validation datasets (n = 1871). All-SGA (birthweight /= 3500 g, >12 months to conceive, university student, cigarette smoking, proteinuria, daily vigorous exercise and diastolic blood pressure >/= 80. Recreational walking >/= 4 times weekly, rhesus negative blood group and increasing random glucose were protective. AUC for clinical risk factors was 0.63. Fetal abdominal or head circumference z scores

Original language	English
Journal	PLoS ONE
Volume	8
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0070917
Publication status	Published - 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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http://www.ncbi.nlm.nih.gov/pubmed/23940665

Cite this

McCowan, L. M., Thompson, J. M., Taylor, R. S., North, R. A., Poston, L., Baker, P. N., Myers, J., Roberts, C. T., Dekker, G. A., Simpson, N. A., Walker, J. J., & Kenny, L. C. (2013). Clinical prediction in early pregnancy of infants small for gestational age by customised birthweight centiles: findings from a healthy nulliparous cohort. PLoS ONE, 8(8). https://doi.org/10.1371/journal.pone.0070917

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title = "Clinical prediction in early pregnancy of infants small for gestational age by customised birthweight centiles: findings from a healthy nulliparous cohort",

abstract = "OBJECTIVE: Small for gestational age (SGA) infants comprise up to 50\% of all stillbirths and a minority are detected before birth. We aimed to develop and validate early pregnancy predictive models for SGA infants. METHODS: 5628 participants from SCOPE, a prospective study of nulliparous pregnant women, were interviewed at 15 +/- 1 weeks' gestation. Fetal anthropometry, uterine and umbilical Doppler studies were performed at 20 +/- 1 weeks'. The cohort was divided into training (n = 3735) and validation datasets (n = 1871). All-SGA (birthweight /= 3500 g, >12 months to conceive, university student, cigarette smoking, proteinuria, daily vigorous exercise and diastolic blood pressure >/= 80. Recreational walking >/= 4 times weekly, rhesus negative blood group and increasing random glucose were protective. AUC for clinical risk factors was 0.63. Fetal abdominal or head circumference z scores",

author = "McCowan, \{L M\} and Thompson, \{J M\} and Taylor, \{R S\} and North, \{R A\} and L Poston and Baker, \{P N\} and J Myers and Roberts, \{C T\} and Dekker, \{G A\} and Simpson, \{N A\} and Walker, \{J J\} and Kenny, \{L C\}",

note = "McCowan, Lesley M E Thompson, John M D Taylor, Rennae S North, Robyn A Poston, Lucilla Baker, Philip N Myers, Jenny Roberts, Claire T Dekker, Gustaaf A Simpson, Nigel A B Walker, James J Kenny, Louise C SCOPE Consortium Biotechnology and Biological Sciences Research Council/United Kingdom PLoS One. 2013 Aug 5;8(8):e70917. doi: 10.1371/journal.pone.0070917. Print 2013.",

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McCowan, LM, Thompson, JM, Taylor, RS, North, RA, Poston, L, Baker, PN, Myers, J, Roberts, CT, Dekker, GA, Simpson, NA, Walker, JJ & Kenny, LC 2013, 'Clinical prediction in early pregnancy of infants small for gestational age by customised birthweight centiles: findings from a healthy nulliparous cohort', PLoS ONE, vol. 8, no. 8. https://doi.org/10.1371/journal.pone.0070917

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T1 - Clinical prediction in early pregnancy of infants small for gestational age by customised birthweight centiles: findings from a healthy nulliparous cohort

AU - McCowan, L M

AU - Thompson, J M

AU - Taylor, R S

AU - North, R A

AU - Poston, L

AU - Baker, P N

AU - Myers, J

AU - Roberts, C T

AU - Dekker, G A

AU - Simpson, N A

AU - Walker, J J

AU - Kenny, L C

N1 - McCowan, Lesley M E Thompson, John M D Taylor, Rennae S North, Robyn A Poston, Lucilla Baker, Philip N Myers, Jenny Roberts, Claire T Dekker, Gustaaf A Simpson, Nigel A B Walker, James J Kenny, Louise C SCOPE Consortium Biotechnology and Biological Sciences Research Council/United Kingdom PLoS One. 2013 Aug 5;8(8):e70917. doi: 10.1371/journal.pone.0070917. Print 2013.

PY - 2013

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N2 - OBJECTIVE: Small for gestational age (SGA) infants comprise up to 50% of all stillbirths and a minority are detected before birth. We aimed to develop and validate early pregnancy predictive models for SGA infants. METHODS: 5628 participants from SCOPE, a prospective study of nulliparous pregnant women, were interviewed at 15 +/- 1 weeks' gestation. Fetal anthropometry, uterine and umbilical Doppler studies were performed at 20 +/- 1 weeks'. The cohort was divided into training (n = 3735) and validation datasets (n = 1871). All-SGA (birthweight /= 3500 g, >12 months to conceive, university student, cigarette smoking, proteinuria, daily vigorous exercise and diastolic blood pressure >/= 80. Recreational walking >/= 4 times weekly, rhesus negative blood group and increasing random glucose were protective. AUC for clinical risk factors was 0.63. Fetal abdominal or head circumference z scores

AB - OBJECTIVE: Small for gestational age (SGA) infants comprise up to 50% of all stillbirths and a minority are detected before birth. We aimed to develop and validate early pregnancy predictive models for SGA infants. METHODS: 5628 participants from SCOPE, a prospective study of nulliparous pregnant women, were interviewed at 15 +/- 1 weeks' gestation. Fetal anthropometry, uterine and umbilical Doppler studies were performed at 20 +/- 1 weeks'. The cohort was divided into training (n = 3735) and validation datasets (n = 1871). All-SGA (birthweight /= 3500 g, >12 months to conceive, university student, cigarette smoking, proteinuria, daily vigorous exercise and diastolic blood pressure >/= 80. Recreational walking >/= 4 times weekly, rhesus negative blood group and increasing random glucose were protective. AUC for clinical risk factors was 0.63. Fetal abdominal or head circumference z scores

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JO - PLoS ONE

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ER -

Clinical prediction in early pregnancy of infants small for gestational age by customised birthweight centiles: findings from a healthy nulliparous cohort

Abstract

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