Clinical Trials Radiographers identifying priority challenges associated with implementing a national programme of clinical trials in the United Kingdom’s first proton beam therapy centre

Lucy S C Davies; Louise McHugh; Sally Falk; Jacqui Bridge; Philip F Amaro; Lee Whiteside; Rachael Bailey; Julie Webb; Cynthia L Eccles

doi:10.1093/bjro/tzae012

Clinical Trials Radiographers identifying priority challenges associated with implementing a national programme of clinical trials in the United Kingdom’s first proton beam therapy centre

Lucy S C Davies, Louise McHugh, Sally Falk, Jacqui Bridge, Philip F Amaro, Lee Whiteside, Rachael Bailey, Julie Webb, Cynthia L Eccles

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVES: This article is an evaluation of the current trial processes within a national proton beam therapy (PBT) clinical trial service in the United Kingdom. The work within the article identifies priority challenges associated with the implementation of PBT trials with a view to improving patient trial processes.

METHODS: The nominal group technique (NGT) was used. Five Clinical Trials Radiographers were asked the target question "what are the major challenges when implementing PBT clinical trials and facilitating PBT trial-related activities?" Participants individually and silently listed their challenges to the target question. Following this, group discussion clarified and refined responses. Participants then individually selected five challenges that they deemed most pertinent to the target question, giving a weighted score (out of 10). Individual scores were combined to provide a ranked, weighted order of challenges. Further group discussion identified improvement strategies to the highest scored challenges.

RESULTS: After combining lists generated by participants, 59 challenges were identified. Group discussion eliminated 27 responses. Eighteen were merged, resulting in 14 challenges. The two challenges that ranked highest were: (i) lack of initial understanding of the responsibilities of teams and who the relevant stakeholders were, and (ii) that a national PBT service requires the provision of shared care across multi-disciplinary teams and sites. Improvement areas include the development of shared protocols, clarifying stakeholder responsibilities and improving communication between centres to streamline PBT trial processes.

CONCLUSIONS: This work has identified priority areas requiring development to improve the conduct of a national PBT clinical trials programme.

ADVANCES IN KNOWLEDGE: This is the first publication to evaluate current clinical trial processes for the United Kingdom's PBT service.

Original language	English
Article number	tzae012
Journal	BJR\|Open
Volume	6
Issue number	1
DOIs	https://doi.org/10.1093/bjro/tzae012
Publication status	Published - 23 May 2024

Keywords

proton beam therapy
clinical trials
nominal group technique

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10.1093/bjro/tzae012Licence: CC BY

NIHR Manchester Biomedical Research Centre
Bruce, I. (PI), Lord, G. (CoI), Lennon, R. (CoI), Black, G. (CoI), Wedge, D. (CoI), Morris, A. (CoI), Hussell, T. (CoI), Sharrocks, A. (CoI), Stivaros, S. (CoI), Buch, M. (CoI), Gough, J. (CoI), Kostarelos, K. (CoI), Thistlethwaite, F. (CoI), Kadler, K. (CoI), Barton, A. (CoI), Hyrich, K. (CoI), Mcbeth, J. (CoI), O'Neill, T. (CoI), Vestbo, J. (CoI), Simpson, A. (CoI), Singh, S. (CoI), Smith, J. (CoI), Felton, T. (CoI), Murray, C. (CoI), Griffiths, C. (CoI), Cullum, N. (CoI), Rhodes, L. (CoI), Warren, R. (CoI), Paus, R. (CoI), Dumville, J. (CoI), Viros Usandizaga, A. (CoI), Keavney, B. (CoI), Tomaszewski, M. (CoI), Allan, S. (CoI), Body, R. (CoI), Cartwright, E. (CoI), Heagerty, A. (CoI), Kalra, P. (CoI), Miller, C. (CoI), Rutter, M. (CoI), Smith, C. (CoI), Trafford, A. (CoI), Evans, D. (CoI), Crosbie, E. (CoI), Crosbie, P. (CoI), Harvie, M. (CoI), Howell, S. (CoI), Renehan, A. (CoI), Dive, C. (CoI), Blackhall, F. (CoI), Landers, D. (CoI), Krebs, M. (CoI), Cook, N. (CoI), Clarke, R. (CoI), Taylor, S. (CoI), Jorgensen, C. (CoI), Lorigan, P. (CoI), Jayson, G. (CoI), Valle, J. (CoI), Mccabe, M. (CoI), Armstrong, A. (CoI), Freitas, A. (CoI), Illidge, T. (CoI), Choudhury, A. (CoI), Hoskin, P. (CoI), West, C. (CoI), Van Herk, M. (CoI), Faivre-Finn, C. (CoI), Bristow, R. (CoI), Kirkby, K. (CoI), Birtle, A. (CoI), Mackay, R. (CoI), Radford, J. (CoI), Linton, K. (CoI), Higham, C. (CoI), Munro, K. (CoI), Plack, C. (CoI), Arden Armitage, C. (CoI), Bruce, I. (CoI), Moore, D. (CoI), Saunders, G. (CoI), Stone, M. (CoI), Haddock, G. (CoI), Lewis, S. (CoI), Elliott, R. (CoI), Green, J. (CoI), Lovell, K. (CoI), Morrison, A. (CoI), Shaw, J. (CoI), Bucci, S. (CoI), Ainsworth, J. (CoI), Webb, R. (CoI), Newman, W. (CoI), Banka, S. (CoI), Clayton-Smith, J. (CoI), Payne, K. (CoI), Moldovan, R. (CoI), Wynn, R. (CoI) & Jones, S. (CoI)
1/12/22 → 30/11/27
Project: Research

Cite this

Davies, L. S. C., McHugh, L., Falk, S., Bridge, J., Amaro, P. F., Whiteside, L., Bailey, R., Webb, J., & Eccles, C. L. (2024). Clinical Trials Radiographers identifying priority challenges associated with implementing a national programme of clinical trials in the United Kingdom’s first proton beam therapy centre. BJR|Open, 6(1), Article tzae012. https://doi.org/10.1093/bjro/tzae012

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title = "Clinical Trials Radiographers identifying priority challenges associated with implementing a national programme of clinical trials in the United Kingdom{\textquoteright}s first proton beam therapy centre",

abstract = "OBJECTIVES: This article is an evaluation of the current trial processes within a national proton beam therapy (PBT) clinical trial service in the United Kingdom. The work within the article identifies priority challenges associated with the implementation of PBT trials with a view to improving patient trial processes.METHODS: The nominal group technique (NGT) was used. Five Clinical Trials Radiographers were asked the target question {"}what are the major challenges when implementing PBT clinical trials and facilitating PBT trial-related activities?{"} Participants individually and silently listed their challenges to the target question. Following this, group discussion clarified and refined responses. Participants then individually selected five challenges that they deemed most pertinent to the target question, giving a weighted score (out of 10). Individual scores were combined to provide a ranked, weighted order of challenges. Further group discussion identified improvement strategies to the highest scored challenges.RESULTS: After combining lists generated by participants, 59 challenges were identified. Group discussion eliminated 27 responses. Eighteen were merged, resulting in 14 challenges. The two challenges that ranked highest were: (i) lack of initial understanding of the responsibilities of teams and who the relevant stakeholders were, and (ii) that a national PBT service requires the provision of shared care across multi-disciplinary teams and sites. Improvement areas include the development of shared protocols, clarifying stakeholder responsibilities and improving communication between centres to streamline PBT trial processes.CONCLUSIONS: This work has identified priority areas requiring development to improve the conduct of a national PBT clinical trials programme.ADVANCES IN KNOWLEDGE: This is the first publication to evaluate current clinical trial processes for the United Kingdom's PBT service.",

keywords = "proton beam therapy, clinical trials, nominal group technique",

author = "Davies, {Lucy S C} and Louise McHugh and Sally Falk and Jacqui Bridge and Amaro, {Philip F} and Lee Whiteside and Rachael Bailey and Julie Webb and Eccles, {Cynthia L}",

year = "2024",

month = may,

day = "23",

doi = "10.1093/bjro/tzae012",

language = "English",

volume = "6",

journal = "BJR|Open",

issn = "2513-9878",

publisher = "British Institute of Radiology",

number = "1",

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Davies, LSC, McHugh, L, Falk, S, Bridge, J, Amaro, PF, Whiteside, L, Bailey, R, Webb, J & Eccles, CL 2024, 'Clinical Trials Radiographers identifying priority challenges associated with implementing a national programme of clinical trials in the United Kingdom’s first proton beam therapy centre', BJR|Open, vol. 6, no. 1, tzae012. https://doi.org/10.1093/bjro/tzae012

TY - JOUR

T1 - Clinical Trials Radiographers identifying priority challenges associated with implementing a national programme of clinical trials in the United Kingdom’s first proton beam therapy centre

AU - Davies, Lucy S C

AU - McHugh, Louise

AU - Falk, Sally

AU - Bridge, Jacqui

AU - Amaro, Philip F

AU - Whiteside, Lee

AU - Bailey, Rachael

AU - Webb, Julie

AU - Eccles, Cynthia L

PY - 2024/5/23

Y1 - 2024/5/23

N2 - OBJECTIVES: This article is an evaluation of the current trial processes within a national proton beam therapy (PBT) clinical trial service in the United Kingdom. The work within the article identifies priority challenges associated with the implementation of PBT trials with a view to improving patient trial processes.METHODS: The nominal group technique (NGT) was used. Five Clinical Trials Radiographers were asked the target question "what are the major challenges when implementing PBT clinical trials and facilitating PBT trial-related activities?" Participants individually and silently listed their challenges to the target question. Following this, group discussion clarified and refined responses. Participants then individually selected five challenges that they deemed most pertinent to the target question, giving a weighted score (out of 10). Individual scores were combined to provide a ranked, weighted order of challenges. Further group discussion identified improvement strategies to the highest scored challenges.RESULTS: After combining lists generated by participants, 59 challenges were identified. Group discussion eliminated 27 responses. Eighteen were merged, resulting in 14 challenges. The two challenges that ranked highest were: (i) lack of initial understanding of the responsibilities of teams and who the relevant stakeholders were, and (ii) that a national PBT service requires the provision of shared care across multi-disciplinary teams and sites. Improvement areas include the development of shared protocols, clarifying stakeholder responsibilities and improving communication between centres to streamline PBT trial processes.CONCLUSIONS: This work has identified priority areas requiring development to improve the conduct of a national PBT clinical trials programme.ADVANCES IN KNOWLEDGE: This is the first publication to evaluate current clinical trial processes for the United Kingdom's PBT service.

AB - OBJECTIVES: This article is an evaluation of the current trial processes within a national proton beam therapy (PBT) clinical trial service in the United Kingdom. The work within the article identifies priority challenges associated with the implementation of PBT trials with a view to improving patient trial processes.METHODS: The nominal group technique (NGT) was used. Five Clinical Trials Radiographers were asked the target question "what are the major challenges when implementing PBT clinical trials and facilitating PBT trial-related activities?" Participants individually and silently listed their challenges to the target question. Following this, group discussion clarified and refined responses. Participants then individually selected five challenges that they deemed most pertinent to the target question, giving a weighted score (out of 10). Individual scores were combined to provide a ranked, weighted order of challenges. Further group discussion identified improvement strategies to the highest scored challenges.RESULTS: After combining lists generated by participants, 59 challenges were identified. Group discussion eliminated 27 responses. Eighteen were merged, resulting in 14 challenges. The two challenges that ranked highest were: (i) lack of initial understanding of the responsibilities of teams and who the relevant stakeholders were, and (ii) that a national PBT service requires the provision of shared care across multi-disciplinary teams and sites. Improvement areas include the development of shared protocols, clarifying stakeholder responsibilities and improving communication between centres to streamline PBT trial processes.CONCLUSIONS: This work has identified priority areas requiring development to improve the conduct of a national PBT clinical trials programme.ADVANCES IN KNOWLEDGE: This is the first publication to evaluate current clinical trial processes for the United Kingdom's PBT service.

KW - proton beam therapy

KW - clinical trials

KW - nominal group technique

U2 - 10.1093/bjro/tzae012

DO - 10.1093/bjro/tzae012

M3 - Article

C2 - 38873402

SN - 2513-9878

VL - 6

JO - BJR|Open

JF - BJR|Open

IS - 1

M1 - tzae012

ER -

Clinical Trials Radiographers identifying priority challenges associated with implementing a national programme of clinical trials in the United Kingdom’s first proton beam therapy centre

Abstract

Keywords

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NIHR Manchester Biomedical Research Centre

Cite this