Clinico-pathological and treatment-related factors influencing survival in parotid cancer

A. G. Renehan, E. N. Gleave, N. J. Slevin, M. McGurk

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    One hundred and three patients with primary parotid cancer treated surgically at the Christie Hospital, Manchester, were analysed to assess the influence on survival of prognostic and treatment-related factors. Thirty-seven patients were treated by surgery alone (SG), 66 received post-operative radiation (SG + RT). Median follow-up was 12 years, minimum 5 years. The 10-year disease-specific survival rates for stage I, II and III/IV were 96%, 61% and 17% respectively (P <0.0001). The various histological types segregated into three survival patterns: low-, intermediate- and high-grade with 10-year survival rates of 93%, 41% and 50% respectively (P <0.0001). On multivariate analysis, the factors influencing risk of cancer death in order of importance were: tumour size > 4 cm (P <0.001), presence of nodes (P = 0.001), histology of adenoid cystic carcinoma (P = 0.01), high-tumour grade (P = 0.02) and perineural involvement (P = 0.01). Neither the extent of surgery nor the operator influenced outcome. Overall, adjuvant RT significantly reduced locoregional recurrence (SG + RT 15% vs SG 43%; P = 0.002) but not survival, although on subanalysis, there was a trend to improved survival with large cancers and high-grade tumours. Long-term survival is determined primarily by tumour characteristics, namely clinical stage and grade. Post-operative RT contributes significantly to locoregional control and probably confers some survival advantage in high-risk patients.
    Original languageEnglish
    Pages (from-to)1296-1300
    Number of pages4
    JournalBritish Journal of Cancer
    Issue number8
    Publication statusPublished - 1999


    • Parotid carcinoma
    • Prognostic factors
    • Radiotherapy
    • Surgery


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