TY - JOUR
T1 - Clocking in to immunity
AU - Scheiermann, Christoph
AU - Gibbs, Julie
AU - Ince, Louise
AU - Loudon, Andrew
PY - 2018
Y1 - 2018
N2 - Circadian rhythms are a ubiquitous feature of virtually all living organisms, regulating a wide diversity of physiological systems. It has long been established that the circadian clockwork plays a key role in innate immune responses, and recent studies reveal that several aspects of adaptive immunity are also under circadian control. We discuss the latest insights into the genetic and biochemical mechanisms linking immunity to the core circadian clock of the cell and hypothesize as to why the immune system is so tightly controlled by circadian oscillations. Finally, we consider implications for human health, including vaccination strategies and the emerging field of chrono-immunotherapy.
AB - Circadian rhythms are a ubiquitous feature of virtually all living organisms, regulating a wide diversity of physiological systems. It has long been established that the circadian clockwork plays a key role in innate immune responses, and recent studies reveal that several aspects of adaptive immunity are also under circadian control. We discuss the latest insights into the genetic and biochemical mechanisms linking immunity to the core circadian clock of the cell and hypothesize as to why the immune system is so tightly controlled by circadian oscillations. Finally, we consider implications for human health, including vaccination strategies and the emerging field of chrono-immunotherapy.
UR - http://www.scopus.com/inward/record.url?scp=85045472139&partnerID=8YFLogxK
U2 - 10.1038/s41577-018-0008-4
DO - 10.1038/s41577-018-0008-4
M3 - Article
AN - SCOPUS:85045472139
SN - 1474-1733
SP - 1
EP - 15
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
ER -