Clocking in to immunity

Christoph Scheiermann, Julie Gibbs, Louise Ince, Andrew Loudon

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Circadian rhythms are a ubiquitous feature of virtually all living organisms, regulating a wide diversity of physiological systems. It has long been established that the circadian clockwork plays a key role in innate immune responses, and recent studies reveal that several aspects of adaptive immunity are also under circadian control. We discuss the latest insights into the genetic and biochemical mechanisms linking immunity to the core circadian clock of the cell and hypothesize as to why the immune system is so tightly controlled by circadian oscillations. Finally, we consider implications for human health, including vaccination strategies and the emerging field of chrono-immunotherapy.

Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalNature Reviews Immunology
Early online date16 Apr 2018
Publication statusPublished - 2018


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