Clonal 6p21 rearrangement is restricted to the mesenchymal component of an endometrial polyp

J A Fletcher; J L Pinkus; J M Lage; C C Morton; G S Pinkus

Clonal 6p21 rearrangement is restricted to the mesenchymal component of an endometrial polyp

J A Fletcher, J L Pinkus, J M Lage, C C Morton, G S Pinkus

Division of Evolution, Infection and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

Previous cytogenetic analyses revealed t(6;20)(p21;q13) in two endometrial polyps. We karyotyped a large endometrial polyp in which 19 of 25 metaphase cells contained a t(1;6;4)(q21;p21;q13). Subsequent combined immunohistochemical/cytogenetic analysis showed all aberrant metaphase cells to be of mesenchymal derivation, whereas epithelial cells from the polyp were diploid. These studies indicate that rearrangement of chromosome band 6p21 is a characteristic cytogenetic aberration in the stromal component of endometrial polyps.

Original language	English
Pages (from-to)	260-3
Number of pages	4
Journal	Genes, Chromosomes & Cancer
Volume	5
Issue number	3
Publication status	Published - Oct 1992

Keywords

Aged
Aged, 80 and over
Chromosome Banding
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 6
Endometrial Neoplasms
Female
Humans
Karyotyping
Mesoderm
Polyps
Translocation, Genetic
Journal Article
Research Support, U.S. Gov't, P.H.S.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{b110afcc0ef7457eb405335b7024ae28,

title = "Clonal 6p21 rearrangement is restricted to the mesenchymal component of an endometrial polyp",

abstract = "Previous cytogenetic analyses revealed t(6;20)(p21;q13) in two endometrial polyps. We karyotyped a large endometrial polyp in which 19 of 25 metaphase cells contained a t(1;6;4)(q21;p21;q13). Subsequent combined immunohistochemical/cytogenetic analysis showed all aberrant metaphase cells to be of mesenchymal derivation, whereas epithelial cells from the polyp were diploid. These studies indicate that rearrangement of chromosome band 6p21 is a characteristic cytogenetic aberration in the stromal component of endometrial polyps.",

keywords = "Aged, Aged, 80 and over, Chromosome Banding, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 4, Chromosomes, Human, Pair 6, Endometrial Neoplasms, Female, Humans, Karyotyping, Mesoderm, Polyps, Translocation, Genetic, Journal Article, Research Support, U.S. Gov't, P.H.S.",

author = "Fletcher, {J A} and Pinkus, {J L} and Lage, {J M} and Morton, {C C} and Pinkus, {G S}",

year = "1992",

month = oct,

language = "English",

volume = "5",

pages = "260--3",

journal = "Genes, Chromosomes & Cancer",

issn = "1045-2257",

publisher = "John Wiley & Sons Ltd",

number = "3",

}

TY - JOUR

T1 - Clonal 6p21 rearrangement is restricted to the mesenchymal component of an endometrial polyp

AU - Fletcher, J A

AU - Pinkus, J L

AU - Lage, J M

AU - Morton, C C

AU - Pinkus, G S

PY - 1992/10

Y1 - 1992/10

N2 - Previous cytogenetic analyses revealed t(6;20)(p21;q13) in two endometrial polyps. We karyotyped a large endometrial polyp in which 19 of 25 metaphase cells contained a t(1;6;4)(q21;p21;q13). Subsequent combined immunohistochemical/cytogenetic analysis showed all aberrant metaphase cells to be of mesenchymal derivation, whereas epithelial cells from the polyp were diploid. These studies indicate that rearrangement of chromosome band 6p21 is a characteristic cytogenetic aberration in the stromal component of endometrial polyps.

AB - Previous cytogenetic analyses revealed t(6;20)(p21;q13) in two endometrial polyps. We karyotyped a large endometrial polyp in which 19 of 25 metaphase cells contained a t(1;6;4)(q21;p21;q13). Subsequent combined immunohistochemical/cytogenetic analysis showed all aberrant metaphase cells to be of mesenchymal derivation, whereas epithelial cells from the polyp were diploid. These studies indicate that rearrangement of chromosome band 6p21 is a characteristic cytogenetic aberration in the stromal component of endometrial polyps.

KW - Aged

KW - Aged, 80 and over

KW - Chromosome Banding

KW - Chromosomes, Human, Pair 1

KW - Chromosomes, Human, Pair 4

KW - Chromosomes, Human, Pair 6

KW - Endometrial Neoplasms

KW - Female

KW - Humans

KW - Karyotyping

KW - Mesoderm

KW - Polyps

KW - Translocation, Genetic

KW - Journal Article

KW - Research Support, U.S. Gov't, P.H.S.

M3 - Article

C2 - 1384681

SN - 1045-2257

VL - 5

SP - 260

EP - 263

JO - Genes, Chromosomes & Cancer

JF - Genes, Chromosomes & Cancer

IS - 3

ER -

Clonal 6p21 rearrangement is restricted to the mesenchymal component of an endometrial polyp

Abstract

Keywords

UN SDGs

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