Abstract
In this study, we report the results of cloning, sequencing and functional analysis by complementation test of the putative Cryptococcus neoformans homolog CnSRB1. The nucleotide sequence revealed 63% identity, and the deduced amino acid sequence showed 66 and 64% identity to its respective homolog of Saccharomyces cerevisiae and Candida albicans, respectively. Functional complementation test indicated that the putative CnSRB1 gene could compensate the defect caused by a mutation in ScSRB1 in the S. cerevisiae srb1 mutant. Taken together, these results suggest that the putative CnSrb1p is a functional homolog of ScSrb1p.
| Original language | English |
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| Pages (from-to) | 484-491 |
| Number of pages | 7 |
| Journal | Southeast Asian Journal of Tropical Medicine and Public Health |
| Volume | 39 |
| Issue number | 3 |
| Publication status | Published - May 2008 |