Closed-loop insulin delivery in type 1 diabetes

Hood Thabit; Roman Hovorka

doi:10.1016/j.ecl.2011.12.003

Closed-loop insulin delivery in type 1 diabetes

Hood Thabit, Roman Hovorka

Division of Diabetes, Endocrinology & Gastroenterology (L5)

Research output: Contribution to journal › Review article › peer-review

Abstract

Advances in diabetes technology have led to significant improvements in the quality of life and care received by individuals with diabetes. Despite this, achieving tight glycemic control through intensive insulin therapy and modern insulin regimens is challenging because of the barrier of hypoglycemia, the most feared complication of insulin therapy as reported by patients, caregivers, and physicians. This article outlines the individual components of the closed-loop system together with the existing clinical evidence. The artificial pancreas prototypes currently used in clinical studies are reviewed as well as obstacles and limitations facing the technology.

Original language	English
Pages (from-to)	105-17
Number of pages	13
Journal	Endocrinology and Metabolism Clinics of North America
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/j.ecl.2011.12.003
Publication status	Published - Mar 2012

Keywords

Blood Glucose
Diabetes Mellitus, Type 1/blood
Humans
Hypoglycemic Agents/administration & dosage
Insulin/administration & dosage
Insulin Infusion Systems

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ecl.2011.12.003

Cite this

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abstract = "Advances in diabetes technology have led to significant improvements in the quality of life and care received by individuals with diabetes. Despite this, achieving tight glycemic control through intensive insulin therapy and modern insulin regimens is challenging because of the barrier of hypoglycemia, the most feared complication of insulin therapy as reported by patients, caregivers, and physicians. This article outlines the individual components of the closed-loop system together with the existing clinical evidence. The artificial pancreas prototypes currently used in clinical studies are reviewed as well as obstacles and limitations facing the technology.",

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AU - Hovorka, Roman

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AB - Advances in diabetes technology have led to significant improvements in the quality of life and care received by individuals with diabetes. Despite this, achieving tight glycemic control through intensive insulin therapy and modern insulin regimens is challenging because of the barrier of hypoglycemia, the most feared complication of insulin therapy as reported by patients, caregivers, and physicians. This article outlines the individual components of the closed-loop system together with the existing clinical evidence. The artificial pancreas prototypes currently used in clinical studies are reviewed as well as obstacles and limitations facing the technology.

KW - Blood Glucose

KW - Diabetes Mellitus, Type 1/blood

KW - Humans

KW - Hypoglycemic Agents/administration & dosage

KW - Insulin/administration & dosage

KW - Insulin Infusion Systems

U2 - 10.1016/j.ecl.2011.12.003

DO - 10.1016/j.ecl.2011.12.003

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JO - Endocrinology and Metabolism Clinics of North America

JF - Endocrinology and Metabolism Clinics of North America

IS - 1

ER -

Closed-loop insulin delivery in type 1 diabetes

Abstract

Keywords

UN SDGs

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