Closed-loop insulin delivery in type 1 diabetes

Hood Thabit, Roman Hovorka

Research output: Contribution to journalReview articlepeer-review


Advances in diabetes technology have led to significant improvements in the quality of life and care received by individuals with diabetes. Despite this, achieving tight glycemic control through intensive insulin therapy and modern insulin regimens is challenging because of the barrier of hypoglycemia, the most feared complication of insulin therapy as reported by patients, caregivers, and physicians. This article outlines the individual components of the closed-loop system together with the existing clinical evidence. The artificial pancreas prototypes currently used in clinical studies are reviewed as well as obstacles and limitations facing the technology.

Original languageEnglish
Pages (from-to)105-17
Number of pages13
JournalEndocrinology and Metabolism Clinics of North America
Issue number1
Publication statusPublished - Mar 2012


  • Blood Glucose
  • Diabetes Mellitus, Type 1/blood
  • Humans
  • Hypoglycemic Agents/administration & dosage
  • Insulin/administration & dosage
  • Insulin Infusion Systems


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