Co-electrospun brain mimetic hollow microfibres fibres for diffusion magnetic resonance imaging

F.-L. Zhou, P.L. Hubbard Cristinacce, S.J. Eichhorn, G.J.M. Parker

Research output: Chapter in Book/Report/Conference proceedingChapter


Diffusion magnetic resonance imaging (dMRI) provides a non-invasive tool to explore biological tissues, including brain with its highly organised hierarchical fibrous structures. An MR phantom is a test object with known size and material for the calibration of MR scanners and the validation of image processing algorithms. Despite extensive research on the development of brain-mimicking phantoms, there are significant problems with using the existing phantoms for dMRI. This chapter is designed to lead the reader through the development of brain-mimetic phantoms for application in dMRI. Our starting point is a brief introduction to the dMRI technique and phantoms previously developed to mimic brain tissues. The second section focuses on the preparation and characterization of novel physical phantoms composed of co-electrospun hollow microfibres. Finally, the evaluation of the developed co-electrospun phantoms is presented in the third section.
Original languageEnglish
Title of host publicationElectrospinning for High Performance Sensors
EditorsAntonella Macagnano, Emiliano Zampetti, Erich Kny
Place of PublicationCham, Switzerland
PublisherSpringer Cham
Number of pages16
ISBN (Electronic)9783319144061
ISBN (Print)9783319144054, 9783319381787
Publication statusPublished - 20 Apr 2015

Publication series

NameNanoScience and Technology
PublisherSpringer Cham
ISSN (Print)1434-4904
ISSN (Electronic)2197-7127


  • diffusion MRI
  • brain phantom
  • co-electrospinning
  • hollow microfibres


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