Co-registration of magnetoencephalography with magnetic resonance imaging using bite-bar-based fiducials and surface-matching

P. Adjamian, G. R. Barnes, A. Hillebrand, I. E. Holliday, K. D. Singh, P. L. Furlong, E. Harrington, C. W. Barclay, P. J G Route

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objective: To introduce a new technique for co-registration of Magnetoencephalography (MEG) with magnetic resonance imaging (MRI). We compare the accuracy of a new bite-bar with fixed fiducials to a previous technique whereby fiducial coils were attached proximal to landmarks on the skull. Methods: A bite-bar with fixed fiducial coils is used to determine the position of the head in the MEG co-ordinate system. Co-registration is performed by a surface-matching technique. The advantage of fixing the coils is that the co-ordinate system is not based upon arbitrary and operator dependent fiducial points that are attached to landmarks (e.g. nasion and the preauricular points), but rather on those that are permanently fixed in relation to the skull. Results: As a consequence of minimizing coil movement during digitization, errors in localization of the coils are significantly reduced, as shown by a randomization test. Displacement of the bite-bar caused by removal and repositioning between MEG recordings is minimal (∼0.5 mm), and dipole localization accuracy of a somatosensory mapping paradigm shows a repeatability of ∼5 mm. The overall accuracy of the new procedure is greatly improved compared to the previous technique. Conclusions: The test-retest reliability and accuracy of target localization with the new design is superior to techniques that incorporate anatomical-based fiducial points or coils placed on the circumference of the head. © 2003 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)691-698
    Number of pages7
    JournalClinical Neurophysiology
    Volume115
    Issue number3
    DOIs
    Publication statusPublished - Mar 2004

    Keywords

    • Bite-bar
    • Fiducial localization error
    • MEG-MRI co-registration
    • Monte Carlo simulation
    • Target registration error

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