Co-stimulation: Novel methods for preventing viral-induced lung inflammation

Tracy Hussell, Robert Snelgrove, Ian R. Humphreys, Andrew E. Williams

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Respiratory infections cause significant morbidity and mortality worldwide. Although an immune response is required to eliminate respiratory pathogens, if unchecked, it can damage surrounding tissues and block primary lung function. Based on our knowledge of immune T-cell activation, there are several pathways to which immune intervention could be applied. However, relatively few interventions target only those immune cells that are responding to antigens. OX40 and 4-1BB are members of the tumour necrosis factor receptor family and are expressed on the surface of T cells in several inflammatory conditions. Recently, the inhibition of OX40 has proved beneficial during influenza virus infection. This review highlights the recent advances in the manipulation of such molecules and how they have been applied to inflammatory conditions that are caused by viruses in the lung.
    Original languageEnglish
    Pages (from-to)379-386
    Number of pages7
    JournalTrends in molecular medicine
    Volume10
    Issue number8
    DOIs
    Publication statusPublished - 1 Aug 2004

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