Coexistence of treatment-related MLL cleavage and rearrangement in a child with haemophagocytic lymphohistiocytosis

A. Ng, P. F. Ravetto, G. M. Taylor, R. F. Wynn, O. B. Eden

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Treatment-related acute myeloid leukaemia (t-AML) is a serious complication of topoisomerase 2 inhibitor therapy and is characterised by the presence of mixed lineage leukaemia (MLL) rearrangement. By molecular tracking, we were able to show that MLL cleavage preceded gene rearrangement by 3 months and before the clinical diagnosis of t-AML in a patient with haemophagocytic lymphohistiocytosis. This is the first report on the sequential detection of the two biomarkers in treatment-related leukaemogenesis. © 2004 Cancer Research UK.
    Original languageEnglish
    Pages (from-to)1990-1992
    Number of pages2
    JournalBritish Journal of Cancer
    Volume91
    Issue number12
    Publication statusPublished - 13 Dec 2004

    Keywords

    • HLH
    • MLL cleavage and rearrangement
    • Treatment-related leukaemia

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