TY - JOUR
T1 - Cognition in children with Neurofibromatosis type 1: Data from a Population-based study
AU - Lehtonen, Annukka
AU - Garg, Shruti
AU - Roberts, Stephen A
AU - Trump, D
AU - Evans, D Gareth
AU - Green, J
AU - Huson, SM
PY - 2015
Y1 - 2015
N2 - Aim This study aimed to investigate the core cognitive deficits in children with neurofibromatosis type 1 (NF1). Method The study recruited 49 children with NF1 (25 males, 24 females; mean age 11y 9mo [SD 3y 2mo]), 19 healthy siblings of children with NF1 (sibling comparisons; mean age 12y 7mo [SD 2y 7mo], 9 males, 10 females) and 29 healthy children from the community (community comparisons; mean age 11y [SD 2y 7mo], 12 males, 17 females). Participants completed a battery of cognitive tests including tests of intelligence, academic achievement, attention, visuoperceptual functioning, visual learning, executive functioning, and non-verbal working memory tests. Results Our study, using a population-based sample, confirmed previous findings from studies using variable sampling methods. Children with NF1 had significantly lower Full-scale IQs (p=0.04) and lower academic achievement (p=0.026–0.005) than their siblings. Compared with their siblings, they also had significantly poorer visuospatial processing (p=0.007), visual associate learning (p=0.014), non-verbal working memory (p=0.023), and executive function (p
AB - Aim This study aimed to investigate the core cognitive deficits in children with neurofibromatosis type 1 (NF1). Method The study recruited 49 children with NF1 (25 males, 24 females; mean age 11y 9mo [SD 3y 2mo]), 19 healthy siblings of children with NF1 (sibling comparisons; mean age 12y 7mo [SD 2y 7mo], 9 males, 10 females) and 29 healthy children from the community (community comparisons; mean age 11y [SD 2y 7mo], 12 males, 17 females). Participants completed a battery of cognitive tests including tests of intelligence, academic achievement, attention, visuoperceptual functioning, visual learning, executive functioning, and non-verbal working memory tests. Results Our study, using a population-based sample, confirmed previous findings from studies using variable sampling methods. Children with NF1 had significantly lower Full-scale IQs (p=0.04) and lower academic achievement (p=0.026–0.005) than their siblings. Compared with their siblings, they also had significantly poorer visuospatial processing (p=0.007), visual associate learning (p=0.014), non-verbal working memory (p=0.023), and executive function (p
U2 - 10.1111/dmcn.12734
DO - 10.1111/dmcn.12734
M3 - Article
SN - 1939-5086
VL - 57
SP - 645
EP - 651
JO - Wiley Interdisciplinary Reviews: Cognitive Science (Online)
JF - Wiley Interdisciplinary Reviews: Cognitive Science (Online)
IS - 7
ER -