Cognitive dysfunction and emotional-behavioural changes in MS: The potential of positron emission tomography

Karl Herholz

doi:10.1016/j.jns.2005.09.012

Cognitive dysfunction and emotional-behavioural changes in MS: The potential of positron emission tomography

Research output: Contribution to journal › Article › peer-review

Abstract

Cognitive dysfunction and emotional-behavioral changes are symptoms with increasing clinical relevance during progression of the disease. They cannot be explained by demyelination of white matter alone but clearly indicate cortical dysfunction. Positron emission tomography (PET) provides methods to assess cortical dysfunction quantitatively by measuring cerebral glucose metabolism using the tracer 18F-2-fluoro-2-deoxy-d-glucose (FDG). The technique has been employed to study fatigue and disease progression. Microglial activation was studied by 11C-PK-11195 PET. It was found not only in active plaques but also in degenerating fibre tracks. Other tracers offer a broad spectrum of measuring local physiological functions and pathophysiological processes, but some of them are still limited to experimental animal research. © 2006 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	9-13
Number of pages	4
Journal	JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume	245
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jns.2005.09.012
Publication status	Published - 15 Jun 2006

Keywords

Cerebral glucose metabolism
Cognitive dysfunction
Microglia
Molecular imaging
Multiple sclerosis
Positron emission tomography

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10.1016/j.jns.2005.09.012

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abstract = "Cognitive dysfunction and emotional-behavioral changes are symptoms with increasing clinical relevance during progression of the disease. They cannot be explained by demyelination of white matter alone but clearly indicate cortical dysfunction. Positron emission tomography (PET) provides methods to assess cortical dysfunction quantitatively by measuring cerebral glucose metabolism using the tracer 18F-2-fluoro-2-deoxy-d-glucose (FDG). The technique has been employed to study fatigue and disease progression. Microglial activation was studied by 11C-PK-11195 PET. It was found not only in active plaques but also in degenerating fibre tracks. Other tracers offer a broad spectrum of measuring local physiological functions and pathophysiological processes, but some of them are still limited to experimental animal research. {\textcopyright} 2006 Elsevier B.V. All rights reserved.",

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AB - Cognitive dysfunction and emotional-behavioral changes are symptoms with increasing clinical relevance during progression of the disease. They cannot be explained by demyelination of white matter alone but clearly indicate cortical dysfunction. Positron emission tomography (PET) provides methods to assess cortical dysfunction quantitatively by measuring cerebral glucose metabolism using the tracer 18F-2-fluoro-2-deoxy-d-glucose (FDG). The technique has been employed to study fatigue and disease progression. Microglial activation was studied by 11C-PK-11195 PET. It was found not only in active plaques but also in degenerating fibre tracks. Other tracers offer a broad spectrum of measuring local physiological functions and pathophysiological processes, but some of them are still limited to experimental animal research. © 2006 Elsevier B.V. All rights reserved.

KW - Cerebral glucose metabolism

KW - Cognitive dysfunction

KW - Microglia

KW - Molecular imaging

KW - Multiple sclerosis

KW - Positron emission tomography

U2 - 10.1016/j.jns.2005.09.012

DO - 10.1016/j.jns.2005.09.012

M3 - Article

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JO - JOURNAL OF THE NEUROLOGICAL SCIENCES

JF - JOURNAL OF THE NEUROLOGICAL SCIENCES

IS - 1-2

ER -

Cognitive dysfunction and emotional-behavioural changes in MS: The potential of positron emission tomography

Abstract

Keywords

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