Cognitive evolutionary therapy versus standard cognitive therapy for depression: A single-blinded randomized clinical trial

Cezar Giosan; Oana Cobeanu; Katarzyna Wyka; Vlad Muresan; Cristina Mogoase; Aurora Szentagotai; Loretta S Malta; Ramona Moldovan

doi:10.1002/jclp.22991

Cognitive evolutionary therapy versus standard cognitive therapy for depression: A single-blinded randomized clinical trial

Cezar Giosan, Oana Cobeanu, Katarzyna Wyka, Vlad Muresan, Cristina Mogoase, Aurora Szentagotai, Loretta S Malta, Ramona Moldovan

Division of Evolution, Infection and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To compare the efficacy of cognitive evolutionary therapy (CET) with cognitive therapy (CT) for depression.

METHODS: Ninety-seven participants (78 females/19 males) were randomized to a single-blinded controlled trial (CET: n = 51 vs. CT: n = 46). Assessments were conducted at baseline, Sessions 4 and 8, posttreatment, and 3-month follow-up. Clinical diagnoses were made with Structured Clinical Interview for DSM-IV (SCID) and self-reports for depression and secondary outcomes.

RESULTS: Although both groups showed significant reductions in depressive symptomatology, the overall Time × Treatment group interaction in the intent to treat analysis was not significant (p = .770, posttreatment: d = 0.39). However, CET was superior to CT at increasing engagement in social and enjoyable activities (p = .040, posttreatment: d = 0.83, p = .040) and showed greater reductions than the CT group in behavioral inhibition/avoidance (p = .047, d = 0.62). The between-group differences generally diminished at the 3-month follow-up.

CONCLUSIONS: CET is a novel therapy for depression that may add therapeutic benefits beyond those of CT.

Original language	English
Pages (from-to)	1818-1831
Number of pages	14
Journal	Journal of Clinical Psychology
Volume	76
Issue number	10
DOIs	https://doi.org/10.1002/jclp.22991
Publication status	Published - Oct 2020

Keywords

Adult
Cognitive Behavioral Therapy/methods
Depression/psychology
Female
Follow-Up Studies
Humans
Male
Single-Blind Method
Treatment Outcome

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10.1002/jclp.22991

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title = "Cognitive evolutionary therapy versus standard cognitive therapy for depression: A single-blinded randomized clinical trial",

abstract = "OBJECTIVE: To compare the efficacy of cognitive evolutionary therapy (CET) with cognitive therapy (CT) for depression.METHODS: Ninety-seven participants (78 females/19 males) were randomized to a single-blinded controlled trial (CET: n = 51 vs. CT: n = 46). Assessments were conducted at baseline, Sessions 4 and 8, posttreatment, and 3-month follow-up. Clinical diagnoses were made with Structured Clinical Interview for DSM-IV (SCID) and self-reports for depression and secondary outcomes.RESULTS: Although both groups showed significant reductions in depressive symptomatology, the overall Time × Treatment group interaction in the intent to treat analysis was not significant (p = .770, posttreatment: d = 0.39). However, CET was superior to CT at increasing engagement in social and enjoyable activities (p = .040, posttreatment: d = 0.83, p = .040) and showed greater reductions than the CT group in behavioral inhibition/avoidance (p = .047, d = 0.62). The between-group differences generally diminished at the 3-month follow-up.CONCLUSIONS: CET is a novel therapy for depression that may add therapeutic benefits beyond those of CT.",

keywords = "Adult, Cognitive Behavioral Therapy/methods, Depression/psychology, Female, Follow-Up Studies, Humans, Male, Single-Blind Method, Treatment Outcome",

author = "Cezar Giosan and Oana Cobeanu and Katarzyna Wyka and Vlad Muresan and Cristina Mogoase and Aurora Szentagotai and Malta, \{Loretta S\} and Ramona Moldovan",

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doi = "10.1002/jclp.22991",

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T2 - A single-blinded randomized clinical trial

AU - Giosan, Cezar

AU - Cobeanu, Oana

AU - Wyka, Katarzyna

AU - Muresan, Vlad

AU - Mogoase, Cristina

AU - Szentagotai, Aurora

AU - Malta, Loretta S

AU - Moldovan, Ramona

PY - 2020/10

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N2 - OBJECTIVE: To compare the efficacy of cognitive evolutionary therapy (CET) with cognitive therapy (CT) for depression.METHODS: Ninety-seven participants (78 females/19 males) were randomized to a single-blinded controlled trial (CET: n = 51 vs. CT: n = 46). Assessments were conducted at baseline, Sessions 4 and 8, posttreatment, and 3-month follow-up. Clinical diagnoses were made with Structured Clinical Interview for DSM-IV (SCID) and self-reports for depression and secondary outcomes.RESULTS: Although both groups showed significant reductions in depressive symptomatology, the overall Time × Treatment group interaction in the intent to treat analysis was not significant (p = .770, posttreatment: d = 0.39). However, CET was superior to CT at increasing engagement in social and enjoyable activities (p = .040, posttreatment: d = 0.83, p = .040) and showed greater reductions than the CT group in behavioral inhibition/avoidance (p = .047, d = 0.62). The between-group differences generally diminished at the 3-month follow-up.CONCLUSIONS: CET is a novel therapy for depression that may add therapeutic benefits beyond those of CT.

AB - OBJECTIVE: To compare the efficacy of cognitive evolutionary therapy (CET) with cognitive therapy (CT) for depression.METHODS: Ninety-seven participants (78 females/19 males) were randomized to a single-blinded controlled trial (CET: n = 51 vs. CT: n = 46). Assessments were conducted at baseline, Sessions 4 and 8, posttreatment, and 3-month follow-up. Clinical diagnoses were made with Structured Clinical Interview for DSM-IV (SCID) and self-reports for depression and secondary outcomes.RESULTS: Although both groups showed significant reductions in depressive symptomatology, the overall Time × Treatment group interaction in the intent to treat analysis was not significant (p = .770, posttreatment: d = 0.39). However, CET was superior to CT at increasing engagement in social and enjoyable activities (p = .040, posttreatment: d = 0.83, p = .040) and showed greater reductions than the CT group in behavioral inhibition/avoidance (p = .047, d = 0.62). The between-group differences generally diminished at the 3-month follow-up.CONCLUSIONS: CET is a novel therapy for depression that may add therapeutic benefits beyond those of CT.

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KW - Cognitive Behavioral Therapy/methods

KW - Depression/psychology

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Single-Blind Method

KW - Treatment Outcome

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ER -

Cognitive evolutionary therapy versus standard cognitive therapy for depression: A single-blinded randomized clinical trial

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