Cognitive theory and therapy of anxiety and depression: Convergence with neurobiological findings

David A. Clark, Aaron T. Beck

    Research output: Contribution to journalArticlepeer-review

    Abstract

    In this review paper a modified cognitive neurophysiological model of Aaron T. Beck's cognitive formulation of anxiety and depression is proposed that provides an elaborated account of the cognitive and neural mediational processes of cognitive therapy (CT). Empirical evidence consistent with this model is discussed that indicates the effectiveness of cognitive therapy could be associated with reduced activation of the amygdalohippocampal subcortical regions implicated in the generation of negative emotion and increased activation of higher-order frontal regions involved in cognitive control of negative emotion. Future cognitive neuroscience research is needed on the unique brain substrates affected by CT and their role in facilitating symptom change. This future research would have important implications for improving the efficiency and efficacy of this treatment approach. © 2010 Elsevier Ltd.
    Original languageEnglish
    Pages (from-to)418-424
    Number of pages6
    JournalTrends in Cognitive Sciences
    Volume14
    Issue number9
    DOIs
    Publication statusPublished - Sep 2010

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