Cold atmospheric pressure plasma jet interactions with plasmid DNA

D. O'Connell; L. J. Cox; W. B. Hyland; S. J. McMahon; S. Reuter; W. G. Graham; T. Gans; F. J. Currell

doi:10.1063/1.3521502

Cold atmospheric pressure plasma jet interactions with plasmid DNA

D. O'Connell, L. J. Cox, W. B. Hyland, S. J. McMahon, S. Reuter, W. G. Graham, T. Gans, F. J. Currell

Dalton Nuclear Institute

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of a cold (<40 °C) radio frequency-driven atmospheric pressure plasma jet on plasmid DNA has been investigated. Gel electrophoresis was used to analyze the DNA forms post-treatment. The experimental data are fitted to a rate equation model that allows for quantitative determination of the rates of single and double strand break formation. The formation of double strand breaks correlates well with the atomic oxygen density. Taken with other measurements, this indicates that neutral components in the jet are effective in inducing double strand breaks.

Original language	English
Number of pages	4
Journal	Applied Physics Letters
Volume	98
Issue number	4
DOIs	https://doi.org/10.1063/1.3521502
Publication status	Published - 24 Jan 2011

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Dalton Nuclear Institute

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10.1063/1.3521502

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abstract = "The effect of a cold (<40 °C) radio frequency-driven atmospheric pressure plasma jet on plasmid DNA has been investigated. Gel electrophoresis was used to analyze the DNA forms post-treatment. The experimental data are fitted to a rate equation model that allows for quantitative determination of the rates of single and double strand break formation. The formation of double strand breaks correlates well with the atomic oxygen density. Taken with other measurements, this indicates that neutral components in the jet are effective in inducing double strand breaks.",

author = "D. O'Connell and Cox, {L. J.} and Hyland, {W. B.} and McMahon, {S. J.} and S. Reuter and Graham, {W. G.} and T. Gans and Currell, {F. J.}",

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AU - O'Connell, D.

AU - Cox, L. J.

AU - Hyland, W. B.

AU - McMahon, S. J.

AU - Reuter, S.

AU - Graham, W. G.

AU - Gans, T.

AU - Currell, F. J.

PY - 2011/1/24

Y1 - 2011/1/24

N2 - The effect of a cold (<40 °C) radio frequency-driven atmospheric pressure plasma jet on plasmid DNA has been investigated. Gel electrophoresis was used to analyze the DNA forms post-treatment. The experimental data are fitted to a rate equation model that allows for quantitative determination of the rates of single and double strand break formation. The formation of double strand breaks correlates well with the atomic oxygen density. Taken with other measurements, this indicates that neutral components in the jet are effective in inducing double strand breaks.

AB - The effect of a cold (<40 °C) radio frequency-driven atmospheric pressure plasma jet on plasmid DNA has been investigated. Gel electrophoresis was used to analyze the DNA forms post-treatment. The experimental data are fitted to a rate equation model that allows for quantitative determination of the rates of single and double strand break formation. The formation of double strand breaks correlates well with the atomic oxygen density. Taken with other measurements, this indicates that neutral components in the jet are effective in inducing double strand breaks.

U2 - 10.1063/1.3521502

DO - 10.1063/1.3521502

M3 - Article

SN - 0003-6951

VL - 98

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 4

ER -

Cold atmospheric pressure plasma jet interactions with plasmid DNA

Abstract

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