Collagenase inhibitor concentration in cultured cervical tissue of sheep is increased in late pregnancy

J. G. Raynes, F. A. Clarke, J. C. Anderson, R. J. Fitzpatrick, H. Dobson

    Research output: Contribution to journalArticlepeer-review

    Abstract

    An inhibitor of collagenase was released from cultured cervical tissue of sheep and the amounts released were greatest from tissue in late pregnancy (145-146 days). The molecular weights of material with inhibitory activity, estimated by gel filtration of extracted inhibitor, at different stages of pregnancy were different, i.e. 20000 from extracts of late-pregnant and post-partum samples and 29000 from extracts of non-pregnant samples. Inhibitor from culture supernatants had a molecular weight of 42000. We conclude that the inhibitor has binding characteristics and molecular weights similar to those of the tissue inhibitor of metalloproteinase.
    Original languageEnglish
    Pages (from-to)893-900
    Number of pages7
    JournalJournal of reproduction and fertility
    Volume83
    Issue number2
    Publication statusPublished - 1988

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