Abstract
An inhibitor of collagenase was released from cultured cervical tissue of sheep and the amounts released were greatest from tissue in late pregnancy (145-146 days). The molecular weights of material with inhibitory activity, estimated by gel filtration of extracted inhibitor, at different stages of pregnancy were different, i.e. 20000 from extracts of late-pregnant and post-partum samples and 29000 from extracts of non-pregnant samples. Inhibitor from culture supernatants had a molecular weight of 42000. We conclude that the inhibitor has binding characteristics and molecular weights similar to those of the tissue inhibitor of metalloproteinase.
| Original language | English |
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| Pages (from-to) | 893-900 |
| Number of pages | 7 |
| Journal | Journal of reproduction and fertility |
| Volume | 83 |
| Issue number | 2 |
| Publication status | Published - 1988 |