Colorectal carcinoma to pituitary tumour: tumour to tumour metastasis

Carmine Antonio Donofrio, Cristina Pizzimenti, Ibrahim Djoukhadar, Tara Kearney, Kanna Gnanalingham, Federico Roncaroli

Research output: Contribution to journalArticlepeer-review


We document a patient with colon adenocarcinoma who presented with rapidly worsening visual impairment. Staging computer tomography and subsequent magnetic resonance scans documented a sellar, suprasellar lesion compressing the optic chiasm. The patient underwent trans-sphenoidal surgery to relieve optic chiasm compression and obtain tissue for diagnosis. Histological examination revealed a metastatic mucinous adenocarcinoma in a gonadotroph pituitary neuroendocrine tumour (PitNET, formerly pituitary adenoma). The patient underwent adjuvant radiotherapy to the sella and chemotherapy but he died nine months after pituitary surgery. This report highlights the diagnostic and management challenges of metastases to PitNET.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalBritish journal of neurosurgery
Early online date21 Sept 2020
Publication statusE-pub ahead of print - 21 Sept 2020


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