Combined Notch and PDGF Signaling Enhances Migration and Expression of Stem Cell Markers while Inducing Perivascular Cell Features in Muscle Satellite Cells

Mattia Francesco Maria Gerli; Louise Anne Moyle; Sara Benedetti; Giulia Ferrari; Ekin Ucuncu; Martina Ragazzi; Chrystalla Constantinou; Irene Louca; Hiroshi Sakai; Pierpaolo Ala; Paolo De Coppi; Shahragim Tajbakhsh; Giulio Cossu; Francesco Saverio Tedesco

doi:10.1016/j.stemcr.2019.01.007

Combined Notch and PDGF Signaling Enhances Migration and Expression of Stem Cell Markers while Inducing Perivascular Cell Features in Muscle Satellite Cells

Mattia Francesco Maria Gerli, Louise Anne Moyle, Sara Benedetti, Giulia Ferrari, Ekin Ucuncu, Martina Ragazzi, Chrystalla Constantinou, Irene Louca, Hiroshi Sakai, Pierpaolo Ala, Paolo De Coppi, Shahragim Tajbakhsh, Giulio Cossu, Francesco Saverio Tedesco^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Gerli and Moyle and colleagues show that treatment with molecules involved in developmental specification of pericytes (DLL4 and PDGF-BB) alters satellite cell fate and provides them with features potentially relevant for novel cell therapy protocols.

Original language	English
Pages (from-to)	461-473
Number of pages	13
Journal	Stem Cell Reports
Volume	12
Issue number	3
Early online date	7 Feb 2019
DOIs	https://doi.org/10.1016/j.stemcr.2019.01.007
Publication status	Published - 5 Mar 2019

Keywords

cell therapy
muscle regeneration
muscle stem cells
muscular dystrophy
NOTCH
PDGF
perivascular cells
reprogramming
satellite cells
stem cell fate

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10.1016/j.stemcr.2019.01.007Licence: CC BY

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Gerli, M. F. M., Moyle, L. A., Benedetti, S., Ferrari, G., Ucuncu, E., Ragazzi, M., Constantinou, C., Louca, I., Sakai, H., Ala, P., De Coppi, P., Tajbakhsh, S., Cossu, G., & Tedesco, F. S. (2019). Combined Notch and PDGF Signaling Enhances Migration and Expression of Stem Cell Markers while Inducing Perivascular Cell Features in Muscle Satellite Cells. Stem Cell Reports, 12(3), 461-473. https://doi.org/10.1016/j.stemcr.2019.01.007

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title = "Combined Notch and PDGF Signaling Enhances Migration and Expression of Stem Cell Markers while Inducing Perivascular Cell Features in Muscle Satellite Cells",

abstract = "Gerli and Moyle and colleagues show that treatment with molecules involved in developmental specification of pericytes (DLL4 and PDGF-BB) alters satellite cell fate and provides them with features potentially relevant for novel cell therapy protocols.",

keywords = "cell therapy, muscle regeneration, muscle stem cells, muscular dystrophy, NOTCH, PDGF, perivascular cells, reprogramming, satellite cells, stem cell fate",

author = "Gerli, {Mattia Francesco Maria} and Moyle, {Louise Anne} and Sara Benedetti and Giulia Ferrari and Ekin Ucuncu and Martina Ragazzi and Chrystalla Constantinou and Irene Louca and Hiroshi Sakai and Pierpaolo Ala and {De Coppi}, Paolo and Shahragim Tajbakhsh and Giulio Cossu and Tedesco, {Francesco Saverio}",

year = "2019",

month = mar,

day = "5",

doi = "10.1016/j.stemcr.2019.01.007",

language = "English",

volume = "12",

pages = "461--473",

journal = "Stem Cell Reports",

issn = "2213-6711",

publisher = "Cell Press",

number = "3",

}

Gerli, MFM, Moyle, LA, Benedetti, S, Ferrari, G, Ucuncu, E, Ragazzi, M, Constantinou, C, Louca, I, Sakai, H, Ala, P, De Coppi, P, Tajbakhsh, S, Cossu, G & Tedesco, FS 2019, 'Combined Notch and PDGF Signaling Enhances Migration and Expression of Stem Cell Markers while Inducing Perivascular Cell Features in Muscle Satellite Cells', Stem Cell Reports, vol. 12, no. 3, pp. 461-473. https://doi.org/10.1016/j.stemcr.2019.01.007

TY - JOUR

T1 - Combined Notch and PDGF Signaling Enhances Migration and Expression of Stem Cell Markers while Inducing Perivascular Cell Features in Muscle Satellite Cells

AU - Gerli, Mattia Francesco Maria

AU - Moyle, Louise Anne

AU - Benedetti, Sara

AU - Ferrari, Giulia

AU - Ucuncu, Ekin

AU - Ragazzi, Martina

AU - Constantinou, Chrystalla

AU - Louca, Irene

AU - Sakai, Hiroshi

AU - Ala, Pierpaolo

AU - De Coppi, Paolo

AU - Tajbakhsh, Shahragim

AU - Cossu, Giulio

AU - Tedesco, Francesco Saverio

PY - 2019/3/5

Y1 - 2019/3/5

N2 - Gerli and Moyle and colleagues show that treatment with molecules involved in developmental specification of pericytes (DLL4 and PDGF-BB) alters satellite cell fate and provides them with features potentially relevant for novel cell therapy protocols.

AB - Gerli and Moyle and colleagues show that treatment with molecules involved in developmental specification of pericytes (DLL4 and PDGF-BB) alters satellite cell fate and provides them with features potentially relevant for novel cell therapy protocols.

KW - cell therapy

KW - muscle regeneration

KW - muscle stem cells

KW - muscular dystrophy

KW - NOTCH

KW - PDGF

KW - perivascular cells

KW - reprogramming

KW - satellite cells

KW - stem cell fate

UR - http://www.scopus.com/inward/record.url?scp=85062109759&partnerID=8YFLogxK

U2 - 10.1016/j.stemcr.2019.01.007

DO - 10.1016/j.stemcr.2019.01.007

M3 - Article

AN - SCOPUS:85062109759

SN - 2213-6711

VL - 12

SP - 461

EP - 473

JO - Stem Cell Reports

JF - Stem Cell Reports

IS - 3

ER -

Combined Notch and PDGF Signaling Enhances Migration and Expression of Stem Cell Markers while Inducing Perivascular Cell Features in Muscle Satellite Cells

Abstract

Keywords

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