Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls

W Zheng; B Zhang; Q Cai; H Sung; K Michailidou; J Shi; J Y Choi; J Long; J Dennis; M K Humphreys; Q Wang; W Lu; Y T Gao; C Li; H Cai; S K Park; K Y Yoo; D Y Noh; W Han; A M Dunning; J Benitez; D Vincent; F Bacot; D Tessier; S W Kim; M H Lee; J W Lee; J Y Lee; Y B Xiang; Y Zheng; W Wang; B T Ji; K Matsuo; H Ito; H Iwata; H Tanaka; A H Wu; C C Tseng; D Van Den Berg; D O Stram; S H Teo; C H Yip; I N Kang; T Y Wong; C Y Shen; J C Yu; C S Huang; M F Hou; M Hartman; H Miao; S C Lee; T C Putti; K Muir; A Lophatananon; S Stewart-Brown; P Siriwanarangsan; S Sangrajrang; H Shen; K Chen; P E Wu; Z Ren; C A Haiman; A Sueta; M K Kim; U S Khoo; M Iwasaki; P D Pharoah; W Wen; P Hall; X O Shu; D F Easton; D Kang

doi:10.1093/hmg/ddt089

Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls

W Zheng, B Zhang, Q Cai, H Sung, K Michailidou, J Shi, J Y Choi, J Long, J Dennis, M K Humphreys, Q Wang, W Lu, Y T Gao, C Li, H Cai, S K Park, K Y Yoo, D Y Noh, W Han, A M DunningJ Benitez, D Vincent, F Bacot, D Tessier, S W Kim, M H Lee, J W Lee, J Y Lee, Y B Xiang, Y Zheng, W Wang, B T Ji, K Matsuo, H Ito, H Iwata, H Tanaka, A H Wu, C C Tseng, D Van Den Berg, D O Stram, S H Teo, C H Yip, I N Kang, T Y Wong, C Y Shen, J C Yu, C S Huang, M F Hou, M Hartman, H Miao, S C Lee, T C Putti, K Muir, A Lophatananon, S Stewart-Brown, P Siriwanarangsan, S Sangrajrang, H Shen, K Chen, P E Wu, Z Ren, C A Haiman, A Sueta, M K Kim, U S Khoo, M Iwasaki, P D Pharoah, W Wen, P Hall, X O Shu, D F Easton, D Kang

Research output: Contribution to journal › Article › peer-review

Abstract

In a consortium including 23 637 breast cancer patients and 25 579 controls of East Asian ancestry, we investigated 70 single-nucleotide polymorphisms (SNPs) in 67 independent breast cancer susceptibility loci recently identified by genome-wide association studies (GWASs) conducted primarily in European-ancestry populations. SNPs in 31 loci showed an association with breast cancer risk at P <0.05 in a direction consistent with that reported previously. Twenty-one of them remained statistically significant after adjusting for multiple comparisons with the Bonferroni-corrected significance level of

Original language	English
Journal	Hum Mol Genet
DOIs	https://doi.org/10.1093/hmg/ddt089
Publication status	Published - 2013

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Zheng, W., Zhang, B., Cai, Q., Sung, H., Michailidou, K., Shi, J., Choi, J. Y., Long, J., Dennis, J., Humphreys, M. K., Wang, Q., Lu, W., Gao, Y. T., Li, C., Cai, H., Park, S. K., Yoo, K. Y., Noh, D. Y., Han, W., ... Kang, D. (2013). Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls. Hum Mol Genet. https://doi.org/10.1093/hmg/ddt089

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title = "Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls",

abstract = "In a consortium including 23 637 breast cancer patients and 25 579 controls of East Asian ancestry, we investigated 70 single-nucleotide polymorphisms (SNPs) in 67 independent breast cancer susceptibility loci recently identified by genome-wide association studies (GWASs) conducted primarily in European-ancestry populations. SNPs in 31 loci showed an association with breast cancer risk at P <0.05 in a direction consistent with that reported previously. Twenty-one of them remained statistically significant after adjusting for multiple comparisons with the Bonferroni-corrected significance level of",

author = "W Zheng and B Zhang and Q Cai and H Sung and K Michailidou and J Shi and Choi, {J Y} and J Long and J Dennis and Humphreys, {M K} and Q Wang and W Lu and Gao, {Y T} and C Li and H Cai and Park, {S K} and Yoo, {K Y} and Noh, {D Y} and W Han and Dunning, {A M} and J Benitez and D Vincent and F Bacot and D Tessier and Kim, {S W} and Lee, {M H} and Lee, {J W} and Lee, {J Y} and Xiang, {Y B} and Y Zheng and W Wang and Ji, {B T} and K Matsuo and H Ito and H Iwata and H Tanaka and Wu, {A H} and Tseng, {C C} and {Van Den Berg}, D and Stram, {D O} and Teo, {S H} and Yip, {C H} and Kang, {I N} and Wong, {T Y} and Shen, {C Y} and Yu, {J C} and Huang, {C S} and Hou, {M F} and M Hartman and H Miao and Lee, {S C} and Putti, {T C} and K Muir and A Lophatananon and S Stewart-Brown and P Siriwanarangsan and S Sangrajrang and H Shen and K Chen and Wu, {P E} and Z Ren and Haiman, {C A} and A Sueta and Kim, {M K} and Khoo, {U S} and M Iwasaki and Pharoah, {P D} and W Wen and P Hall and Shu, {X O} and Easton, {D F} and D Kang",

note = "Zheng, Wei Zhang, Ben Cai, Qiuyin Sung, Hyuna Michailidou, Kyriaki Shi, Jiajun Choi, Ji-Yeob Long, Jirong Dennis, Joe Humphreys, Manjeet K Wang, Qin Lu, Wei Gao, Yu-Tang Li, Chun Cai, Hui Park, Sue K Yoo, Keun-Young Noh, Dong-Young Han, Wonshik Dunning, Alison M Benitez, Javier Vincent, Daniel Bacot, Francois Tessier, Daniel Kim, Sung-Won Lee, Min Hyuk Lee, Jong Won Lee, Jong-Young Xiang, Yong-Bing Zheng, Ying Wang, Wenjin Ji, Bu-Tian Matsuo, Keitaro Ito, Hidemi Iwata, Hiroji Tanaka, Hideo Wu, Anna H Tseng, Chiu-Chen Van Den Berg, David Stram, Daniel O Teo, Soo Hwang Yip, Cheng Har Kang, In Nee Wong, Tien Y Shen, Chen-Yang Yu, Jyh-Cherng Huang, Chiun-Sheng Hou, Ming-Feng Hartman, Mikael Miao, Hui Lee, Soo Chin Putti, Thomas Choudary Muir, Kenneth Lophatananon, Artitaya Stewart-Brown, Sarah Siriwanarangsan, Pornthep Sangrajrang, Suleeporn Shen, Hongbing Chen, Kexin Wu, Pei-Ei Ren, Zefang Haiman, Christopher A Sueta, Aiko Kim, Mi Kyung Khoo, Ui Soon Iwasaki, Motoki Pharoah, Paul D P Wen, Wanqing Hall, Per Shu, Xiao-Ou Easton, Douglas F Kang, Daehee Human molecular genetics Hum Mol Genet. 2013 Mar 27.",

year = "2013",

doi = "10.1093/hmg/ddt089",

language = "English",

journal = "Hum Mol Genet",

issn = "0964-6906",

publisher = "Oxford University Press",

}

Zheng, W, Zhang, B, Cai, Q, Sung, H, Michailidou, K, Shi, J, Choi, JY, Long, J, Dennis, J, Humphreys, MK, Wang, Q, Lu, W, Gao, YT, Li, C, Cai, H, Park, SK, Yoo, KY, Noh, DY, Han, W, Dunning, AM, Benitez, J, Vincent, D, Bacot, F, Tessier, D, Kim, SW, Lee, MH, Lee, JW, Lee, JY, Xiang, YB, Zheng, Y, Wang, W, Ji, BT, Matsuo, K, Ito, H, Iwata, H, Tanaka, H, Wu, AH, Tseng, CC, Van Den Berg, D, Stram, DO, Teo, SH, Yip, CH, Kang, IN, Wong, TY, Shen, CY, Yu, JC, Huang, CS, Hou, MF, Hartman, M, Miao, H, Lee, SC, Putti, TC, Muir, K, Lophatananon, A, Stewart-Brown, S, Siriwanarangsan, P, Sangrajrang, S, Shen, H, Chen, K, Wu, PE, Ren, Z, Haiman, CA, Sueta, A, Kim, MK, Khoo, US, Iwasaki, M, Pharoah, PD, Wen, W, Hall, P, Shu, XO, Easton, DF & Kang, D 2013, 'Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls', Hum Mol Genet. https://doi.org/10.1093/hmg/ddt089

TY - JOUR

T1 - Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls

AU - Zheng, W

AU - Zhang, B

AU - Cai, Q

AU - Sung, H

AU - Michailidou, K

AU - Shi, J

AU - Choi, J Y

AU - Long, J

AU - Dennis, J

AU - Humphreys, M K

AU - Wang, Q

AU - Lu, W

AU - Gao, Y T

AU - Li, C

AU - Cai, H

AU - Park, S K

AU - Yoo, K Y

AU - Noh, D Y

AU - Han, W

AU - Dunning, A M

AU - Benitez, J

AU - Vincent, D

AU - Bacot, F

AU - Tessier, D

AU - Kim, S W

AU - Lee, M H

AU - Lee, J W

AU - Lee, J Y

AU - Xiang, Y B

AU - Zheng, Y

AU - Wang, W

AU - Ji, B T

AU - Matsuo, K

AU - Ito, H

AU - Iwata, H

AU - Tanaka, H

AU - Wu, A H

AU - Tseng, C C

AU - Van Den Berg, D

AU - Stram, D O

AU - Teo, S H

AU - Yip, C H

AU - Kang, I N

AU - Wong, T Y

AU - Shen, C Y

AU - Yu, J C

AU - Huang, C S

AU - Hou, M F

AU - Hartman, M

AU - Miao, H

AU - Lee, S C

AU - Putti, T C

AU - Muir, K

AU - Lophatananon, A

AU - Stewart-Brown, S

AU - Siriwanarangsan, P

AU - Sangrajrang, S

AU - Shen, H

AU - Chen, K

AU - Wu, P E

AU - Ren, Z

AU - Haiman, C A

AU - Sueta, A

AU - Kim, M K

AU - Khoo, U S

AU - Iwasaki, M

AU - Pharoah, P D

AU - Wen, W

AU - Hall, P

AU - Shu, X O

AU - Easton, D F

AU - Kang, D

N1 - Zheng, Wei Zhang, Ben Cai, Qiuyin Sung, Hyuna Michailidou, Kyriaki Shi, Jiajun Choi, Ji-Yeob Long, Jirong Dennis, Joe Humphreys, Manjeet K Wang, Qin Lu, Wei Gao, Yu-Tang Li, Chun Cai, Hui Park, Sue K Yoo, Keun-Young Noh, Dong-Young Han, Wonshik Dunning, Alison M Benitez, Javier Vincent, Daniel Bacot, Francois Tessier, Daniel Kim, Sung-Won Lee, Min Hyuk Lee, Jong Won Lee, Jong-Young Xiang, Yong-Bing Zheng, Ying Wang, Wenjin Ji, Bu-Tian Matsuo, Keitaro Ito, Hidemi Iwata, Hiroji Tanaka, Hideo Wu, Anna H Tseng, Chiu-Chen Van Den Berg, David Stram, Daniel O Teo, Soo Hwang Yip, Cheng Har Kang, In Nee Wong, Tien Y Shen, Chen-Yang Yu, Jyh-Cherng Huang, Chiun-Sheng Hou, Ming-Feng Hartman, Mikael Miao, Hui Lee, Soo Chin Putti, Thomas Choudary Muir, Kenneth Lophatananon, Artitaya Stewart-Brown, Sarah Siriwanarangsan, Pornthep Sangrajrang, Suleeporn Shen, Hongbing Chen, Kexin Wu, Pei-Ei Ren, Zefang Haiman, Christopher A Sueta, Aiko Kim, Mi Kyung Khoo, Ui Soon Iwasaki, Motoki Pharoah, Paul D P Wen, Wanqing Hall, Per Shu, Xiao-Ou Easton, Douglas F Kang, Daehee Human molecular genetics Hum Mol Genet. 2013 Mar 27.

PY - 2013

Y1 - 2013

N2 - In a consortium including 23 637 breast cancer patients and 25 579 controls of East Asian ancestry, we investigated 70 single-nucleotide polymorphisms (SNPs) in 67 independent breast cancer susceptibility loci recently identified by genome-wide association studies (GWASs) conducted primarily in European-ancestry populations. SNPs in 31 loci showed an association with breast cancer risk at P <0.05 in a direction consistent with that reported previously. Twenty-one of them remained statistically significant after adjusting for multiple comparisons with the Bonferroni-corrected significance level of

AB - In a consortium including 23 637 breast cancer patients and 25 579 controls of East Asian ancestry, we investigated 70 single-nucleotide polymorphisms (SNPs) in 67 independent breast cancer susceptibility loci recently identified by genome-wide association studies (GWASs) conducted primarily in European-ancestry populations. SNPs in 31 loci showed an association with breast cancer risk at P <0.05 in a direction consistent with that reported previously. Twenty-one of them remained statistically significant after adjusting for multiple comparisons with the Bonferroni-corrected significance level of

U2 - 10.1093/hmg/ddt089

DO - 10.1093/hmg/ddt089

M3 - Article

SN - 0964-6906

JO - Hum Mol Genet

JF - Hum Mol Genet

ER -

Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls

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