Common Genetic Variants Associated with Resting Oxygenation in Chronic Obstructive Pulmonary Disease.

Merry-Lynn McDonald; Michael H Cho; Inga-Cecilie Sorheim; Sharon M Lutz; Peter Castaldi; David A Lomas; Harvey O Coxson; Lisa D Edwards; William MacNee; Jorgen Vestbo; Julie C Yates; Alvar Agusti; Peter Ma Calverley; Bartolome Celli; Courtney Crim; Stephen I Rennard; Emiel Fm Wouters; Per Bakke; Ruth Tal-Singer; Bruce E Miller; Amund Gulsvik; Richard Casaburi; J Michael Wells; Elizabeth A Regan; Barry J Make; John E Hokanson; Christoph Lange; James D Crapo; Terri H Beaty; Edwin K Silverman; Craig P Hersh

doi:10.1165/rcmb.2014-0135OC

Common Genetic Variants Associated with Resting Oxygenation in Chronic Obstructive Pulmonary Disease.

Merry-Lynn McDonald
, Michael H Cho
, Inga-Cecilie Sorheim
, Sharon M Lutz
, Peter Castaldi
, David A Lomas
, Harvey O Coxson
, Lisa D Edwards
, William MacNee
, Jorgen Vestbo
, Julie C Yates
, Alvar Agusti
, Peter Ma Calverley
, Bartolome Celli
, Courtney Crim
, Stephen I Rennard
, Emiel Fm Wouters
, Per Bakke
, Ruth Tal-Singer
, Bruce E Miller

Amund Gulsvik, Richard Casaburi, J Michael Wells, Elizabeth A Regan, Barry J Make, John E Hokanson, Christoph Lange, James D Crapo, Terri H Beaty, Edwin K Silverman, Craig P Hersh

Research output: Contribution to journal › Article › peer-review

Abstract

Hypoxemia is a major complication of Chronic Obstructive Pulmonary Disease (COPD) that correlates with disease prognosis. Identifying genetic variants associated with oxygenation may provide clues for deciphering the heterogeneity in prognosis among COPD patients. However, previous genetic studies have been restricted to investigating COPD candidate genes for association with hypoxemia. To report results from the first genome-wide association study (GWAS) of resting oxygen saturation in COPD cases, we performed a GWAS of pulse oximetry (SpO2) in two large, well-characterized COPD populations: COPDGene, including both the Non-Hispanic White and African American groups, and ECLIPSE. We identified several suggestive loci (P

Original language	English
Journal	American Journal of Respiratory Cell and Molecular Biology
DOIs	https://doi.org/10.1165/rcmb.2014-0135OC
Publication status	Published - 13 May 2014

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McDonald, M.-L., Cho, M. H., Sorheim, I.-C., Lutz, S. M., Castaldi, P., Lomas, D. A., Coxson, H. O., Edwards, L. D., MacNee, W., Vestbo, J., Yates, J. C., Agusti, A., Calverley, P. M., Celli, B., Crim, C., Rennard, S. I., Wouters, E. F., Bakke, P., Tal-Singer, R., ... Hersh, C. P. (2014). Common Genetic Variants Associated with Resting Oxygenation in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory Cell and Molecular Biology. https://doi.org/10.1165/rcmb.2014-0135OC

@article{bf0ea12d10364ea7a00fc8890f7668f8,

title = "Common Genetic Variants Associated with Resting Oxygenation in Chronic Obstructive Pulmonary Disease.",

abstract = "Hypoxemia is a major complication of Chronic Obstructive Pulmonary Disease (COPD) that correlates with disease prognosis. Identifying genetic variants associated with oxygenation may provide clues for deciphering the heterogeneity in prognosis among COPD patients. However, previous genetic studies have been restricted to investigating COPD candidate genes for association with hypoxemia. To report results from the first genome-wide association study (GWAS) of resting oxygen saturation in COPD cases, we performed a GWAS of pulse oximetry (SpO2) in two large, well-characterized COPD populations: COPDGene, including both the Non-Hispanic White and African American groups, and ECLIPSE. We identified several suggestive loci (P",

author = "Merry-Lynn McDonald and Cho, \{Michael H\} and Inga-Cecilie Sorheim and Lutz, \{Sharon M\} and Peter Castaldi and Lomas, \{David A\} and Coxson, \{Harvey O\} and Edwards, \{Lisa D\} and William MacNee and Jorgen Vestbo and Yates, \{Julie C\} and Alvar Agusti and Calverley, \{Peter Ma\} and Bartolome Celli and Courtney Crim and Rennard, \{Stephen I\} and Wouters, \{Emiel Fm\} and Per Bakke and Ruth Tal-Singer and Miller, \{Bruce E\} and Amund Gulsvik and Richard Casaburi and Wells, \{J Michael\} and Regan, \{Elizabeth A\} and Make, \{Barry J\} and Hokanson, \{John E\} and Christoph Lange and Crapo, \{James D\} and Beaty, \{Terri H\} and Silverman, \{Edwin K\} and Hersh, \{Craig P\}",

year = "2014",

month = may,

day = "13",

doi = "10.1165/rcmb.2014-0135OC",

language = "English",

journal = "American Journal of Respiratory Cell and Molecular Biology",

issn = "1535-4989",

publisher = "American Thoracic Society",

}

McDonald, M-L, Cho, MH, Sorheim, I-C, Lutz, SM, Castaldi, P, Lomas, DA, Coxson, HO, Edwards, LD, MacNee, W, Vestbo, J, Yates, JC, Agusti, A, Calverley, PM, Celli, B, Crim, C, Rennard, SI, Wouters, EF, Bakke, P, Tal-Singer, R, Miller, BE, Gulsvik, A, Casaburi, R, Wells, JM, Regan, EA, Make, BJ, Hokanson, JE, Lange, C, Crapo, JD, Beaty, TH, Silverman, EK & Hersh, CP 2014, 'Common Genetic Variants Associated with Resting Oxygenation in Chronic Obstructive Pulmonary Disease.', American Journal of Respiratory Cell and Molecular Biology. https://doi.org/10.1165/rcmb.2014-0135OC

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T1 - Common Genetic Variants Associated with Resting Oxygenation in Chronic Obstructive Pulmonary Disease.

AU - McDonald, Merry-Lynn

AU - Cho, Michael H

AU - Sorheim, Inga-Cecilie

AU - Lutz, Sharon M

AU - Castaldi, Peter

AU - Lomas, David A

AU - Coxson, Harvey O

AU - Edwards, Lisa D

AU - MacNee, William

AU - Vestbo, Jorgen

AU - Yates, Julie C

AU - Agusti, Alvar

AU - Calverley, Peter Ma

AU - Celli, Bartolome

AU - Crim, Courtney

AU - Rennard, Stephen I

AU - Wouters, Emiel Fm

AU - Bakke, Per

AU - Tal-Singer, Ruth

AU - Miller, Bruce E

AU - Gulsvik, Amund

AU - Casaburi, Richard

AU - Wells, J Michael

AU - Regan, Elizabeth A

AU - Make, Barry J

AU - Hokanson, John E

AU - Lange, Christoph

AU - Crapo, James D

AU - Beaty, Terri H

AU - Silverman, Edwin K

AU - Hersh, Craig P

PY - 2014/5/13

Y1 - 2014/5/13

N2 - Hypoxemia is a major complication of Chronic Obstructive Pulmonary Disease (COPD) that correlates with disease prognosis. Identifying genetic variants associated with oxygenation may provide clues for deciphering the heterogeneity in prognosis among COPD patients. However, previous genetic studies have been restricted to investigating COPD candidate genes for association with hypoxemia. To report results from the first genome-wide association study (GWAS) of resting oxygen saturation in COPD cases, we performed a GWAS of pulse oximetry (SpO2) in two large, well-characterized COPD populations: COPDGene, including both the Non-Hispanic White and African American groups, and ECLIPSE. We identified several suggestive loci (P

AB - Hypoxemia is a major complication of Chronic Obstructive Pulmonary Disease (COPD) that correlates with disease prognosis. Identifying genetic variants associated with oxygenation may provide clues for deciphering the heterogeneity in prognosis among COPD patients. However, previous genetic studies have been restricted to investigating COPD candidate genes for association with hypoxemia. To report results from the first genome-wide association study (GWAS) of resting oxygen saturation in COPD cases, we performed a GWAS of pulse oximetry (SpO2) in two large, well-characterized COPD populations: COPDGene, including both the Non-Hispanic White and African American groups, and ECLIPSE. We identified several suggestive loci (P

U2 - 10.1165/rcmb.2014-0135OC

DO - 10.1165/rcmb.2014-0135OC

M3 - Article

C2 - 24825563

SN - 1535-4989

JO - American Journal of Respiratory Cell and Molecular Biology

JF - American Journal of Respiratory Cell and Molecular Biology

ER -

Common Genetic Variants Associated with Resting Oxygenation in Chronic Obstructive Pulmonary Disease.

Abstract

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