Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Malcolm G. Dunlop; Sara E. Dobbins; Susan Mary Farrington; Angela M. Jones; Claire Palles; Nicola Whiffin; Albert Tenesa; Sarah Spain; Peter Broderick; Li Yin Ooi; Enric Domingo; Claire Smillie; Marc Henrion; Matthew Frampton; Lynn Martin; Graeme Grimes; Maggie Gorman; Colin Semple; Yusanne P. Ma; Huw Thomas; Gareth Evans; Alex Henderson; Andrew Green; Christopher G. Smith; Graham MacDonald; David Smith; Liam Grogan; Robert Thomas; Richard Wilson; Andrew Hindley; Shabbir Susnerwala; Edward Levine; Saifee Mullamitha; Mark Saunders; Juan Valle; Adam Jones; Mohammad Butt; David Wilson; Mark Harrison; Alison Birtle; Andrew Webb; Amanda Jones; Paul O'Neill; Rachel Cooper; Emma Alexander; Elizabeth Toy; Rachel Williams; Richard Adams; Chris Parker; Julia Brown

doi:10.1038/ng.2293

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Malcolm G. Dunlop^*, Sara E. Dobbins, Susan Mary Farrington, Angela M. Jones, Claire Palles, Nicola Whiffin, Albert Tenesa, Sarah Spain, Peter Broderick, Li Yin Ooi, Enric Domingo, Claire Smillie, Marc Henrion, Matthew Frampton, Lynn Martin, Graeme Grimes, Maggie Gorman, Colin Semple, Yusanne P. Ma, Huw ThomasGareth Evans, Alex Henderson, Andrew Green, Christopher G. Smith, Graham MacDonald, David Smith, Liam Grogan, Robert Thomas, Richard Wilson, Andrew Hindley, Shabbir Susnerwala, Edward Levine, Saifee Mullamitha, Mark Saunders, Juan Valle, Adam Jones, Mohammad Butt, David Wilson, Mark Harrison, Alison Birtle, Andrew Webb, Amanda Jones, Paul O'Neill, Rachel Cooper, Emma Alexander, Elizabeth Toy, Rachel Williams, Richard Adams, Chris Parker, Julia Brown

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

Abstract

We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10 ^-10), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10 ^-10) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10 ^-10) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.

Original language	English
Pages (from-to)	770-776
Number of pages	7
Journal	Nature Genetics
Volume	44
Issue number	7
DOIs	https://doi.org/10.1038/ng.2293
Publication status	Published - 1 Jul 2012

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10.1038/ng.2293

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Dunlop, M. G., Dobbins, S. E., Farrington, S. M., Jones, A. M., Palles, C., Whiffin, N., Tenesa, A., Spain, S., Broderick, P., Ooi, L. Y., Domingo, E., Smillie, C., Henrion, M., Frampton, M., Martin, L., Grimes, G., Gorman, M., Semple, C., Ma, Y. P., ... Brown, J. (2012). Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk. Nature Genetics, 44(7), 770-776. https://doi.org/10.1038/ng.2293

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title = "Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk",

abstract = "We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10 -10), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10 -10) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10 -10) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.",

author = "Dunlop, {Malcolm G.} and Dobbins, {Sara E.} and Farrington, {Susan Mary} and Jones, {Angela M.} and Claire Palles and Nicola Whiffin and Albert Tenesa and Sarah Spain and Peter Broderick and Ooi, {Li Yin} and Enric Domingo and Claire Smillie and Marc Henrion and Matthew Frampton and Lynn Martin and Graeme Grimes and Maggie Gorman and Colin Semple and Ma, {Yusanne P.} and Huw Thomas and Gareth Evans and Alex Henderson and Andrew Green and Smith, {Christopher G.} and Graham MacDonald and David Smith and Liam Grogan and Robert Thomas and Richard Wilson and Andrew Hindley and Shabbir Susnerwala and Edward Levine and Saifee Mullamitha and Mark Saunders and Juan Valle and Adam Jones and Mohammad Butt and David Wilson and Mark Harrison and Alison Birtle and Andrew Webb and Amanda Jones and Paul O'Neill and Rachel Cooper and Emma Alexander and Elizabeth Toy and Rachel Williams and Richard Adams and Chris Parker and Julia Brown",

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doi = "10.1038/ng.2293",

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Dunlop, MG, Dobbins, SE, Farrington, SM, Jones, AM, Palles, C, Whiffin, N, Tenesa, A, Spain, S, Broderick, P, Ooi, LY, Domingo, E, Smillie, C, Henrion, M, Frampton, M, Martin, L, Grimes, G, Gorman, M, Semple, C, Ma, YP, Thomas, H, Evans, G, Henderson, A, Green, A, Smith, CG, MacDonald, G, Smith, D, Grogan, L, Thomas, R, Wilson, R, Hindley, A, Susnerwala, S, Levine, E, Mullamitha, S, Saunders, M, Valle, J, Jones, A, Butt, M, Wilson, D, Harrison, M, Birtle, A, Webb, A, Jones, A, O'Neill, P, Cooper, R, Alexander, E, Toy, E, Williams, R, Adams, R, Parker, C & Brown, J 2012, 'Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk', Nature Genetics, vol. 44, no. 7, pp. 770-776. https://doi.org/10.1038/ng.2293

TY - JOUR

T1 - Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

AU - Dunlop, Malcolm G.

AU - Dobbins, Sara E.

AU - Farrington, Susan Mary

AU - Jones, Angela M.

AU - Palles, Claire

AU - Whiffin, Nicola

AU - Tenesa, Albert

AU - Spain, Sarah

AU - Broderick, Peter

AU - Ooi, Li Yin

AU - Domingo, Enric

AU - Smillie, Claire

AU - Henrion, Marc

AU - Frampton, Matthew

AU - Martin, Lynn

AU - Grimes, Graeme

AU - Gorman, Maggie

AU - Semple, Colin

AU - Ma, Yusanne P.

AU - Thomas, Huw

AU - Evans, Gareth

AU - Henderson, Alex

AU - Green, Andrew

AU - Smith, Christopher G.

AU - MacDonald, Graham

AU - Smith, David

AU - Grogan, Liam

AU - Thomas, Robert

AU - Wilson, Richard

AU - Hindley, Andrew

AU - Susnerwala, Shabbir

AU - Levine, Edward

AU - Mullamitha, Saifee

AU - Saunders, Mark

AU - Valle, Juan

AU - Jones, Adam

AU - Butt, Mohammad

AU - Wilson, David

AU - Harrison, Mark

AU - Birtle, Alison

AU - Webb, Andrew

AU - Jones, Amanda

AU - O'Neill, Paul

AU - Cooper, Rachel

AU - Alexander, Emma

AU - Toy, Elizabeth

AU - Williams, Rachel

AU - Adams, Richard

AU - Parker, Chris

AU - Brown, Julia

PY - 2012/7/1

Y1 - 2012/7/1

N2 - We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10 -10), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10 -10) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10 -10) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.

AB - We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10 -10), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10 -10) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10 -10) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.

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DO - 10.1038/ng.2293

M3 - Letter

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AN - SCOPUS:84863005628

SN - 1061-4036

VL - 44

SP - 770

EP - 776

JO - Nature Genetics

JF - Nature Genetics

IS - 7

ER -

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

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