Comparative genomic and phylogenetic analysis of vitellogenin and other large lipid transfer proteins in metazoans

Alexander Hayward; Tokiharu Takahashi; William G. Bendena; Stephen S. Tobe; Jerome H L Hui

doi:10.1016/j.febslet.2010.02.056

Comparative genomic and phylogenetic analysis of vitellogenin and other large lipid transfer proteins in metazoans

Alexander Hayward
, Tokiharu Takahashi
, William G. Bendena
, Stephen S. Tobe
, Jerome H L Hui

Research output: Contribution to journal › Article › peer-review

Abstract

Vitellogenins and other large lipid transfer proteins (LLTP) are well known to play significant roles in the development, metabolism and reproduction of animals. Comparative genomics and phylogenetic analyses of LLTPs using the most comprehensive dataset in metazoans to date are carried out. Our analyses demonstrate that LLTP genes arose significantly earlier, and are more widespread than previously proposed - being present in numerous additional bilaterian and non-bilaterian lineages. A hypothesis is advanced that the most ancestral animal LLTP gene is Vtg, while loss of domains occurred at the bilaterians stem giving rise to apolipoprotein and microsomal triglyceride transfer proteins genes. © 2010 Federation of European Biochemical Societies.

Original language	English
Pages (from-to)	1273-1278
Number of pages	5
Journal	FEBS Letters
Volume	584
Issue number	6
DOIs	https://doi.org/10.1016/j.febslet.2010.02.056
Publication status	Published - Mar 2010

Keywords

Apolipoprotein
Cnidaria
Microsomal triglyceride transfer protein
Phylogeny
Placozoa
Vitellogenin

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10.1016/j.febslet.2010.02.056

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title = "Comparative genomic and phylogenetic analysis of vitellogenin and other large lipid transfer proteins in metazoans",

abstract = "Vitellogenins and other large lipid transfer proteins (LLTP) are well known to play significant roles in the development, metabolism and reproduction of animals. Comparative genomics and phylogenetic analyses of LLTPs using the most comprehensive dataset in metazoans to date are carried out. Our analyses demonstrate that LLTP genes arose significantly earlier, and are more widespread than previously proposed - being present in numerous additional bilaterian and non-bilaterian lineages. A hypothesis is advanced that the most ancestral animal LLTP gene is Vtg, while loss of domains occurred at the bilaterians stem giving rise to apolipoprotein and microsomal triglyceride transfer proteins genes. {\textcopyright} 2010 Federation of European Biochemical Societies.",

keywords = "Apolipoprotein, Cnidaria, Microsomal triglyceride transfer protein, Phylogeny, Placozoa, Vitellogenin",

author = "Alexander Hayward and Tokiharu Takahashi and Bendena, \{William G.\} and Tobe, \{Stephen S.\} and Hui, \{Jerome H L\}",

year = "2010",

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doi = "10.1016/j.febslet.2010.02.056",

language = "English",

volume = "584",

pages = "1273--1278",

journal = "FEBS Letters",

publisher = "John Wiley \& Sons Ltd",

number = "6",

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TY - JOUR

T1 - Comparative genomic and phylogenetic analysis of vitellogenin and other large lipid transfer proteins in metazoans

AU - Hayward, Alexander

AU - Takahashi, Tokiharu

AU - Bendena, William G.

AU - Tobe, Stephen S.

AU - Hui, Jerome H L

PY - 2010/3

Y1 - 2010/3

N2 - Vitellogenins and other large lipid transfer proteins (LLTP) are well known to play significant roles in the development, metabolism and reproduction of animals. Comparative genomics and phylogenetic analyses of LLTPs using the most comprehensive dataset in metazoans to date are carried out. Our analyses demonstrate that LLTP genes arose significantly earlier, and are more widespread than previously proposed - being present in numerous additional bilaterian and non-bilaterian lineages. A hypothesis is advanced that the most ancestral animal LLTP gene is Vtg, while loss of domains occurred at the bilaterians stem giving rise to apolipoprotein and microsomal triglyceride transfer proteins genes. © 2010 Federation of European Biochemical Societies.

AB - Vitellogenins and other large lipid transfer proteins (LLTP) are well known to play significant roles in the development, metabolism and reproduction of animals. Comparative genomics and phylogenetic analyses of LLTPs using the most comprehensive dataset in metazoans to date are carried out. Our analyses demonstrate that LLTP genes arose significantly earlier, and are more widespread than previously proposed - being present in numerous additional bilaterian and non-bilaterian lineages. A hypothesis is advanced that the most ancestral animal LLTP gene is Vtg, while loss of domains occurred at the bilaterians stem giving rise to apolipoprotein and microsomal triglyceride transfer proteins genes. © 2010 Federation of European Biochemical Societies.

KW - Apolipoprotein

KW - Cnidaria

KW - Microsomal triglyceride transfer protein

KW - Phylogeny

KW - Placozoa

KW - Vitellogenin

U2 - 10.1016/j.febslet.2010.02.056

DO - 10.1016/j.febslet.2010.02.056

M3 - Article

C2 - 20188099

VL - 584

SP - 1273

EP - 1278

JO - FEBS Letters

JF - FEBS Letters

IS - 6

ER -

Comparative genomic and phylogenetic analysis of vitellogenin and other large lipid transfer proteins in metazoans

Abstract

Keywords

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