Comparing C60+ and (H2O)n+ clusters for mouse brain tissue analysis

Irma Berrueta Razo, Sadia Sheraz, Alex Henderson, Nicholas P. Lockyer, John C. Vickerman

    Research output: Contribution to journalArticlepeer-review


    Time-of-flight SIMS is applied to the analysis of single cells and different types of biological tissue samples enabling the generation of images with high spatial resolution and chemical specificity. However, the low yield of secondary ions from this type of sample still remains a challenge. This low yield could potentially be increased by enhancing the protonation of ions with the presence of water. Here, we have explored the application of a prototype water cluster ion beam for the analysis of mouse brain tissue samples. A series of experiments acquired with 20keV (H2O)3000+ and 20keV (H2O)4500+ were compared with 20keV C60+, showing ion yield enhancement when a (H2O)n+ cluster ion is employed in the analysis. The results have demonstrated the potential benefits provided by the use of (H2O)n+ clusters for the analysis of mouse brain tissue samples. © 2014 The Authors Surface and Interface Analysis Published by John Wiley & Sons Ltd.
    Original languageEnglish
    Pages (from-to)136–139
    Number of pages4
    JournalSurface and Interface Analysis
    Issue numberS1
    Early online date25 Nov 2014
    Publication statusPublished - Nov 2014


    • C60
    • Cluster comparison
    • H2O
    • Imaging
    • SIMS
    • Tissue analysis

    Research Beacons, Institutes and Platforms

    • Manchester Institute of Biotechnology


    Dive into the research topics of 'Comparing C60+ and (H2O)n+ clusters for mouse brain tissue analysis'. Together they form a unique fingerprint.

    Cite this