Comparing two methods of using toxicity outcomes to study dose-response mapping of bladder and rectum in prostate cancer patients undergoing radiotherapy

Research output: Contribution to conferencePoster

Abstract

Voxel-based analysis (VBA), such as radiotherapy dose-response maps (DRM) derived by combining dose-surface maps (DSM) and toxicity outcomes, aims to identify high-risk sub-regions in organs at risk (OARs). The study aims to assess the differences between two different methods of using late toxicities, namely, with and without baseline normalization, for identifying high-risk sub-regions on DRM of the bladder and rectum in prostate cancer (PCa) patients undergoing radiotherapy. The selection of the toxicity analysis method, whether with or without baseline normalization, influences the identification of high-risk sub-regions in DRMs of OARs. Subtracting baseline from post-treatment toxicity grades reduces the effectiveness of the dose-response relationship of bladder and rectum in prostate cancer patients undergoing radiotherapy. This influence is primarily attributed to variations in the number of events available for the analysis of each toxicity as other variables were fixed within the DRM methodology. Further efforts are required to enhance the robustness of the methodology, ensuring the generation of more reliable and reproducible results. These results may have implications for other OARs in other cancer types.
Original languageEnglish
Publication statusPublished - Jul 2024
EventXXth International Conference on the use of Computers in Radiation Therapy, 8 - 11 July 2024, Lyon, France - Lyon, France
Duration: 8 Jul 202411 Jul 2024

Conference

ConferenceXXth International Conference on the use of Computers in Radiation Therapy, 8 - 11 July 2024, Lyon, France
Country/TerritoryFrance
CityLyon
Period8/07/2411/07/24

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