Comparison between testosterone enanthate-induced azoospermia and oligozoospermia in a male contraceptive study .5. Localization of higher 5 alpha-reductase activity to the reproductive tract in oligozoospermic men administered supraphysiological doses of testosterone

R A Anderson; R W Kelly; F C W Wu

Comparison between testosterone enanthate-induced azoospermia and oligozoospermia in a male contraceptive study .5. Localization of higher 5 alpha-reductase activity to the reproductive tract in oligozoospermic men administered supraphysiological doses of testosterone

R A Anderson, R W Kelly, F C W Wu

Research output: Contribution to journal › Article › peer-review

Abstract

Sex steroid contraceptive regimens result in incomplete suppression of spermatogenesis in 30-45% of Caucasian men. The basis for this is unclear, but differences in the activity of 5 alpha-reductase (5 alpha R) have been demonstrated. Two isoforms of 5 alpha R have been described: 5 alpha R1 is found in skin, whereas the predominant form in reproductive tissues is 5 alpha R2. To investigate possible contributions of these isoenzymes, we have investigated androgen-dependent changes in seminal plasma androgens (5 alpha R2) and sebum production (5 alpha R1) during administration of a supraphysiological dose (200 mg IM weekly) of testosterone enanthate (TE) to 33 normal men. Eighteen men rapidly (

Original language	English
Pages (from-to)	366-371
Number of pages	6
Journal	Journal of Andrology
Volume	18
Issue number	4
Publication status	Published - 1997

Keywords

male contraception
spermatogenesis
prostaglandin e
seminal plasma
sebum production
human seminal plasma
steroid 5-alpha-reductase
prostaglandin concentrations
rat epididymis
semen
dehydrogenase
deficiency
expression

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Anderson, R A ; Kelly, R W ; Wu, F C W. / Comparison between testosterone enanthate-induced azoospermia and oligozoospermia in a male contraceptive study .5. Localization of higher 5 alpha-reductase activity to the reproductive tract in oligozoospermic men administered supraphysiological doses of testosterone. In: Journal of Andrology. 1997 ; Vol. 18, No. 4. pp. 366-371.

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title = "Comparison between testosterone enanthate-induced azoospermia and oligozoospermia in a male contraceptive study .5. Localization of higher 5 alpha-reductase activity to the reproductive tract in oligozoospermic men administered supraphysiological doses of testosterone",

abstract = "Sex steroid contraceptive regimens result in incomplete suppression of spermatogenesis in 30-45% of Caucasian men. The basis for this is unclear, but differences in the activity of 5 alpha-reductase (5 alpha R) have been demonstrated. Two isoforms of 5 alpha R have been described: 5 alpha R1 is found in skin, whereas the predominant form in reproductive tissues is 5 alpha R2. To investigate possible contributions of these isoenzymes, we have investigated androgen-dependent changes in seminal plasma androgens (5 alpha R2) and sebum production (5 alpha R1) during administration of a supraphysiological dose (200 mg IM weekly) of testosterone enanthate (TE) to 33 normal men. Eighteen men rapidly (",

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Comparison between testosterone enanthate-induced azoospermia and oligozoospermia in a male contraceptive study .5. Localization of higher 5 alpha-reductase activity to the reproductive tract in oligozoospermic men administered supraphysiological doses of testosterone. / Anderson, R A; Kelly, R W; Wu, F C W.
In: Journal of Andrology, Vol. 18, No. 4, 1997, p. 366-371.

Research output: Contribution to journal › Article › peer-review

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