Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor

Katharina G. Hugentobler, Marcello Rasparini, Lisa A. Thompson, Katherine E. Jolley, A. John Blacker, Nicholas J. Turner

Research output: Contribution to journalArticlepeer-review

Abstract

In this study a batch reactor process is compared to a flow chemistry approach for lipase-catalyzed resolution of the cyclopropanecarboxylate ester (±)-3. (1R,2R)-3 is a precursor of the amine (1R,2S)-2 which is a key building block of the API ticagrelor. For both flow and batch operation, the biocatalyst could be recycled several times, whereas in the case of the flow process the reaction time was significantly reduced.

Original languageEnglish
Pages (from-to)195-199
Number of pages5
JournalOrganic Process Research and Development
Volume21
Issue number2
Early online date22 Dec 2016
DOIs
Publication statusPublished - 17 Feb 2017

Keywords

  • batch reactor
  • enzyme catalysis
  • flow chemistry
  • Thermomyces lanuginosus lipase
  • ticagrelor

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