Comparison of Electric- and Magnetic-Cardiograms Produced by Myocardial Ischemia in Models of the Human Ventricle and Torso

Erick Andres Perez Alday, Haibo Ni, Chen Zhang, Michael A. Colman, Zizhao Gan, Henggui Zhang

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Myocardial ventricular ischemia arises from a lack of blood supply to the heart, which may cause abnormal repolarization and
    excitation wave conduction patterns in the tissue, leading to cardiac arrhythmias and even sudden death. Current diagnosis of
    cardiac ischemia by the 12lead
    electrocardiogram (ECG) has limitations as they are insensitive in many cases and may show
    unnoticeable differences to normal patterns. As the magnetic field provides extra information on cardiac excitation and is more
    sensitive to tangential currents to the surface of the chest, whereas the electric field is more sensitive to flux currents, it has been
    hypothesized that the magnetocardiogram (MCG) may provide a complementary method to the ECG in ischemic diagnosis.
    However, it is unclear yet about the differences in sensitivity regions of body surface ECG and MCG signals to ischemic conditions.
    The aim of this study was to investigate such differences by using 12,
    36ECG
    and 36MCG
    computed from multiscale
    biophysically detailed computational models of the human ventricles and torso in both control and ischemic conditions. It was
    shown that ischemia produced changes in the ECG and MCG signals in the QRS complex, Twave
    and STsegment,
    with greater
    relative differences seen in the 36lead
    ECG and MCG as compared to the 12leads
    ECG (34% and 37% vs 26%, respectively).
    The 36lead
    ECG showed more averaged sensitivity than the MCG in the change of Twave
    due to ischemia (37% vs 32%,
    respectively), whereas the MCG showed greater sensitivity than the ECG in the change of the STsegment
    (50% vs 40%,
    respectively). In addition, both MCG and ECG showed regionaldependent
    changes to ischemia, but with MCG showing a stronger
    correlation between ischemic region in the heart. In conclusion, MCG shows more sensitivity than ECG in response to ischemia,
    which may provide an alternative method for the diagnosis of ischemia.
    Original languageEnglish
    JournalP L o S One
    DOIs
    Publication statusPublished - 24 Aug 2016

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