Comparison of extracellular phospholipase activities in clinical and environmental Aspergillus fumigatus isolates

Mike Birch, David W. Denning, Geoffrey D. Robson

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Extracellular phospholipase production by environmental and clinical isolates of Aspergillus fumigatus collected from several centres world-wide were compared. All isolates produced extracellular phospholipases which included phospholipase C and a phospholipid acyl hydrolase (phospholipase A and/or phospholipase B) activity. Clinical isolates of A. fumigatus produced the largest zone sizes in a diffusion assay and clinical isolates produced more extracellular phospholipase C than environmental isolates. However, environmental isolates of A. fumigatus showed increased acyl hydrolase activity compared to clinical isolates of A. fumigatus. This study suggests that extracellular phospholipase C activity, but not extracellular acyl hydrolase activity may be important in the pathogenicity of A. fumigatus.
    Original languageEnglish
    Pages (from-to)81-86
    Number of pages5
    JournalMedical Mycology
    Volume42
    Issue number1
    DOIs
    Publication statusPublished - Feb 2004

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