TY - JOUR
T1 - Comparison of HRRT and HR+ scanners for quantitative (R)-[11C]verapamil, [11C]raclopride and [11C]flumazenil brain studies
AU - Velden, Floris H.P. van
AU - Mansor, Syahir M.
AU - Assema, Daniëlle M.E. van
AU - Berckel, Bart N.M. van
AU - Froklage, Femke E.
AU - Wang, Shaonan
AU - Schuit, Robert C.
AU - Asselin, Marie-Claude
AU - Lammertsma, Adriaan A.
AU - Boellaard, Ronald
AU - Huisman, Marc C.
PY - 2015
Y1 - 2015
N2 - PURPOSE: This study was conducted to directly compare the high-resolution research tomograph (HRRT) (high-resolution brain) and HR+ (standard whole-body) positron emission tomography (PET) only scanners for quantitative brain studies using three tracers with vastly different tracer distributions. PROCEDURES: Healthy volunteers underwent successive scans on HR+ and HRRT scanners (in random order) using either (R)-[11C]verapamil (n = 6), [11C]raclopride (n = 7) or [11C]flumazenil (n = 7). For all tracers, metabolite-corrected plasma-input functions were generated. RESULTS: After resolution matching, HRRT-derived kinetic parameter values correlated well with those of HR+ for all tracers (intraclass correlation coefficients ≥0.78), having a good absolute interscanner test-retest variability (≤15 %). However, systematic differences can be seen for HRRT-derived kinetic parameter values (range -13 to +15 %). CONCLUSION: Quantification of kinetic parameters based on plasma-input models leads to comparable results when spatial resolution between HRRT and HR+ data is matched. When using reference-tissue models, differences remain that are likely caused by differences in attenuation and scatter corrections and/or image reconstruction.
AB - PURPOSE: This study was conducted to directly compare the high-resolution research tomograph (HRRT) (high-resolution brain) and HR+ (standard whole-body) positron emission tomography (PET) only scanners for quantitative brain studies using three tracers with vastly different tracer distributions. PROCEDURES: Healthy volunteers underwent successive scans on HR+ and HRRT scanners (in random order) using either (R)-[11C]verapamil (n = 6), [11C]raclopride (n = 7) or [11C]flumazenil (n = 7). For all tracers, metabolite-corrected plasma-input functions were generated. RESULTS: After resolution matching, HRRT-derived kinetic parameter values correlated well with those of HR+ for all tracers (intraclass correlation coefficients ≥0.78), having a good absolute interscanner test-retest variability (≤15 %). However, systematic differences can be seen for HRRT-derived kinetic parameter values (range -13 to +15 %). CONCLUSION: Quantification of kinetic parameters based on plasma-input models leads to comparable results when spatial resolution between HRRT and HR+ data is matched. When using reference-tissue models, differences remain that are likely caused by differences in attenuation and scatter corrections and/or image reconstruction.
U2 - 10.1007/s11307-014-0766-8
DO - 10.1007/s11307-014-0766-8
M3 - Article
SN - 1860-2002
JO - Molecular Imaging and Biology
JF - Molecular Imaging and Biology
ER -