Comparison of neurokinin A and substance P on cardiovascular and airway function in man

T. W. Evans; C. M. Dixon; B. Clarke; T. B. Conradson; P. J. Barnes

Comparison of neurokinin A and substance P on cardiovascular and airway function in man

T. W. Evans, C. M. Dixon, B. Clarke, T. B. Conradson, P. J. Barnes

Research output: Contribution to journal › Article › peer-review

Abstract

The airway and cardiovascular effects of intravenous neurokinin A (NKA) and substance P (SP) were compared in six normal subjects. Both SP and NKA increased skin temperature (SkT) and heart rate (HR), but SP was more potent than NKA by factors of 6 and 20 respectively. No change in systolic blood pressure (BP) occurred with either peptide, but diastolic BP fell significantly with SP infusion. SP caused bronchodilation and NKA bronchoconstriction. NKA and SP have differing physiological roles and may activate different receptor populations.

Original language	English
Pages (from-to)	273-275
Number of pages	2
Journal	British Journal of Clinical Pharmacology
Volume	25
Issue number	2
Publication status	Published - 1988

Cite this

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title = "Comparison of neurokinin A and substance P on cardiovascular and airway function in man",

abstract = "The airway and cardiovascular effects of intravenous neurokinin A (NKA) and substance P (SP) were compared in six normal subjects. Both SP and NKA increased skin temperature (SkT) and heart rate (HR), but SP was more potent than NKA by factors of 6 and 20 respectively. No change in systolic blood pressure (BP) occurred with either peptide, but diastolic BP fell significantly with SP infusion. SP caused bronchodilation and NKA bronchoconstriction. NKA and SP have differing physiological roles and may activate different receptor populations.",

author = "Evans, {T. W.} and Dixon, {C. M.} and B. Clarke and Conradson, {T. B.} and Barnes, {P. J.}",

year = "1988",

language = "English",

volume = "25",

pages = "273--275",

journal = "British Journal of Clinical Pharmacology",

issn = "0306-5251",

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T1 - Comparison of neurokinin A and substance P on cardiovascular and airway function in man

AU - Evans, T. W.

AU - Dixon, C. M.

AU - Clarke, B.

AU - Conradson, T. B.

AU - Barnes, P. J.

PY - 1988

Y1 - 1988

N2 - The airway and cardiovascular effects of intravenous neurokinin A (NKA) and substance P (SP) were compared in six normal subjects. Both SP and NKA increased skin temperature (SkT) and heart rate (HR), but SP was more potent than NKA by factors of 6 and 20 respectively. No change in systolic blood pressure (BP) occurred with either peptide, but diastolic BP fell significantly with SP infusion. SP caused bronchodilation and NKA bronchoconstriction. NKA and SP have differing physiological roles and may activate different receptor populations.

AB - The airway and cardiovascular effects of intravenous neurokinin A (NKA) and substance P (SP) were compared in six normal subjects. Both SP and NKA increased skin temperature (SkT) and heart rate (HR), but SP was more potent than NKA by factors of 6 and 20 respectively. No change in systolic blood pressure (BP) occurred with either peptide, but diastolic BP fell significantly with SP infusion. SP caused bronchodilation and NKA bronchoconstriction. NKA and SP have differing physiological roles and may activate different receptor populations.

M3 - Article

C2 - 2451930

SN - 0306-5251

VL - 25

SP - 273

EP - 275

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 2

ER -

Comparison of neurokinin A and substance P on cardiovascular and airway function in man

Abstract

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