Comparison of the “well-stirred” gut and the “QGut” models for predicting intestinal first-pass metabolism.

J Yang; M Jamei; K Rowland-Yeo; GT Tucker; Amin Rostami-Hochaghan

Comparison of the “well-stirred” gut and the “QGut” models for predicting intestinal first-pass metabolism.

J Yang, M Jamei, K Rowland-Yeo, GT Tucker, Amin Rostami-Hochaghan

Research output: Chapter in Book/Conference proceeding › Conference contribution

Abstract

Despite a much lower content of many drug metabolising enzymes in the intestinal epithelium
compared to the liver (e.g. intestinal CYP3A abundance in the intestine is 1% that of the liver
[1,2]), intestinal metabolic extraction may be similar to or even exceed hepatic extraction. The
purpose of this study was to evaluate the performance of two „minimal‟ models, the “well-stirred”
gut model and the “QGut ” model, in predicting intestinal first-pass metabolism from in vitro metabolic data

Original language	English
Title of host publication	host publication
Publication status	Published - Nov 2007
Event	PKUK - Edinburgh Caledonian Hotel, Edinburgh, UK Duration: 14 Nov 2007 → 16 Nov 2007

Conference

Conference	PKUK
City	Edinburgh Caledonian Hotel, Edinburgh, UK
Period	14/11/07 → 16/11/07

Cite this

@inproceedings{8120e031152342ba89d09ff24bcf5be3,

title = "Comparison of the “well-stirred” gut and the “QGut” models for predicting intestinal first-pass metabolism.",

abstract = "Despite a much lower content of many drug metabolising enzymes in the intestinal epitheliumcompared to the liver (e.g. intestinal CYP3A abundance in the intestine is 1% that of the liver[1,2]), intestinal metabolic extraction may be similar to or even exceed hepatic extraction. Thepurpose of this study was to evaluate the performance of two „minimal‟ models, the “well-stirred”gut model and the “QGut ” model, in predicting intestinal first-pass metabolism from in vitro metabolic data",

author = "J Yang and M Jamei and K Rowland-Yeo and GT Tucker and Amin Rostami-Hochaghan",

year = "2007",

month = nov,

language = "English",

booktitle = "host publication",

note = "PKUK ; Conference date: 14-11-2007 Through 16-11-2007",

}

TY - GEN

T1 - Comparison of the “well-stirred” gut and the “QGut” models for predicting intestinal first-pass metabolism.

AU - Yang, J

AU - Jamei, M

AU - Rowland-Yeo, K

AU - Tucker, GT

AU - Rostami-Hochaghan, Amin

PY - 2007/11

Y1 - 2007/11

N2 - Despite a much lower content of many drug metabolising enzymes in the intestinal epitheliumcompared to the liver (e.g. intestinal CYP3A abundance in the intestine is 1% that of the liver[1,2]), intestinal metabolic extraction may be similar to or even exceed hepatic extraction. Thepurpose of this study was to evaluate the performance of two „minimal‟ models, the “well-stirred”gut model and the “QGut ” model, in predicting intestinal first-pass metabolism from in vitro metabolic data

AB - Despite a much lower content of many drug metabolising enzymes in the intestinal epitheliumcompared to the liver (e.g. intestinal CYP3A abundance in the intestine is 1% that of the liver[1,2]), intestinal metabolic extraction may be similar to or even exceed hepatic extraction. Thepurpose of this study was to evaluate the performance of two „minimal‟ models, the “well-stirred”gut model and the “QGut ” model, in predicting intestinal first-pass metabolism from in vitro metabolic data

M3 - Conference contribution

BT - host publication

T2 - PKUK

Y2 - 14 November 2007 through 16 November 2007

ER -

Comparison of the “well-stirred” gut and the “QGut” models for predicting intestinal first-pass metabolism.

Abstract

Conference

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