Comparison of vitamin D2and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: A systematic review and meta-analysis

Laura Tripkovic, Helen Lambert, Kathryn Hart, Colin P. Smith, Giselda Bucca, Simon Penson, Gemma Chope, Elina Hyppon̈en, Jacqueline Berry, Reinhold Vieth, Susan Lanham-New

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background: Currently, there is a lack of clarity in the literature as to whether there is a definitive difference between the effects of vitamins D 2 and D3 in the raising of serum 25-hydroxyvitamin D [25(OH)D]. Objective: The objective of this article was to report a systematic review and meta-analysis of randomized controlled trials (RCTs) that have directly compared the effects of vitamin D2 and vitamin D3 on serum 25(OH)D concentrations in humans. Design: The ISI Web of Knowledge (January 1966 to July 2011) database was searched electronically for all relevant studies in adults that directly compared vitamin D3 with vitamin D2. The Cochrane Clinical Trials Registry, International Standard Randomized Controlled Trials Number register, and clinicaltrials.gov were also searched for any unpublished trials. Results: A meta-analysis of RCTs indicated that supplementation with vitamin D3 had a significant and positive effect in the raising of serum 25(OH)D concentrations compared with the effect of vitamin D2 (P = 0.001). When the frequency of dosage administration was compared, there was a significant response for vitamin D 3 when given as a bolus dose (P = 0.0002) compared with administration of vitamin D2, but the effect was lost with daily supplementation. Conclusions: This meta-analysis indicates that vitamin D 3 is more efficacious at raising serum 25(OH)D concentrations than is vitamin D2, and thus vitamin D3 could potentially become the preferred choice for supplementation. However, additional research is required to examine the metabolic pathways involved in oral and intramuscular administration of vitamin D and the effects across age, sex, and ethnicity, which this review was unable to verify. © 2012 American Society for Nutrition.
    Original languageEnglish
    Pages (from-to)1357-1364
    Number of pages7
    JournalAmerican Journal Of Clinical Nutrition
    Volume95
    Issue number6
    DOIs
    Publication statusPublished - 1 Jun 2012

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