Complement-resistance mechanisms of bacteria

Riina Rautemaa-Richardson; Seppo Meri

doi:10.1016/S1286-4579(99)80081-1

Complement-resistance mechanisms of bacteria

Riina Rautemaa-Richardson, Seppo Meri

Division of Immunology, Immunity to Infection and Respiratory Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Despite more than a century of parallel research on bacteria and the complement system, relatively little is known of the mechanisms whereby pathogenic bacteria can escape complement-related opsonophagocytosis and direct killing. It is likely that pathogenicity in bacteria has arisen more accidentally than in viruses, and on the basis of selection from natural mutants rather than by outright stealing or copying of genetic codes from the host. In this review we will discuss complement resistance as one of the features that makes a bacterium a pathogen.

Original language	English
Pages (from-to)	785-794
Number of pages	9
Journal	Microbes and Infection
Volume	1
Issue number	10
DOIs	https://doi.org/10.1016/S1286-4579(99)80081-1
Publication status	Published - Aug 1999

Keywords

GPI
Salmonella
Streptococcus
Vaccine
Virulence

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10.1016/S1286-4579(99)80081-1

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abstract = "Despite more than a century of parallel research on bacteria and the complement system, relatively little is known of the mechanisms whereby pathogenic bacteria can escape complement-related opsonophagocytosis and direct killing. It is likely that pathogenicity in bacteria has arisen more accidentally than in viruses, and on the basis of selection from natural mutants rather than by outright stealing or copying of genetic codes from the host. In this review we will discuss complement resistance as one of the features that makes a bacterium a pathogen.",

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KW - GPI

KW - Salmonella

KW - Streptococcus

KW - Vaccine

KW - Virulence

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JO - Microbes and Infection

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Complement-resistance mechanisms of bacteria

Abstract

Keywords

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