Complex and differential glial responses in alzheimer´s disease and ageing

José J. Rodríguez, Arthur M. Butt, Emanuela Gardenal, Vladimir Parpura, Alexei Verkhratsky

    Research output: Contribution to journalReview articlepeer-review

    Abstract

    Glial cells and their association with neurones are fundamental for brain function. The emergence of complex neurone-glial networks assures rapid information transfer, creating a sophisticated circuitry where both types of neural cells work in concert, serving different activities. All glial cells, represented by astrocytes, oligodendrocytes, microglia and NG2-glia, are essential for brain homeostasis and defence. Thus, glia are key not only for normal central nervous system (CNS) function, but also to its dysfunction, being directly associated with all forms of neuropathological processes. Therefore, the progression and outcome of neurological and neurodegenerative diseases depend on glial reactions. In this review, we provide a concise account of recent data obtained from both human material and animal models demonstrating the pathological involvement of glia in neurodegenerative processes, including Alzheimer’s disease (AD), as well as physiological ageing.

    Original languageEnglish
    Pages (from-to)343-358
    Number of pages16
    JournalCurrent Alzheimer Research
    Volume13
    Issue number4
    Publication statusPublished - 1 Apr 2016

    Keywords

    • Alzheimer’s disease
    • Astrocytes
    • Atrophy
    • Gliosis
    • Microglia
    • Myelin
    • Neurodegeneration
    • NG2-glia
    • Oligodendrocytes

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